565203-84-1Relevant academic research and scientific papers
Ortho-metalation of p-chloroanisole: A media study
Slocum,Dietzel
, p. 1823 - 1826 (2007/10/03)
As the chlorophenyl group is a pharmacophore, its stability toward metalation conditions in conjunction with the methoxy substituent was assessed. For p-chloroanisole metalation ortho to the methoxy group was achieved in high yield using increments of THF in cyclohexane; numerous other regimes afforded lower yields and a competing benzyne pathway.
