565228-16-2Relevant articles and documents
Thioglycoligases: Mutant glycosidases for thioglycoside synthesis
Jahn, Michael,Marles, Jennifer,Warren, R. Antony J.,Withers, Stephen G.
, p. 352 - 354 (2003)
Engineering of the active site of retaining glycosidases in conjunction with the appropriate modification of their substrates has led to the enzymatic synthesis of thioglycosidic linkages in thiooligosaccharides (see scheme).
Family 4 glycosidases carry out efficient hydrolysis of thioglycosides by an α,β-elimination mechanism
Yip, Vivian L. Y.,Withers, Stephen G.
, p. 6179 - 6182 (2007/10/03)
Thioglycosides are widely used as competitive inhibitors of glycosidases. The first glycosidase capable of hydrolyzing unactivated thioglycosides - BglT, a 6-phospho-β-glucosidase from glucosidase family 4 - has been found. The efficient cleavage of the t