565229-55-2

Upstream product

• 565229-92-7 (1S,2S,3R,6Z,8S,9S,10S,11Z)-5,11-bis(4-methoxybenzyloxy)-16-[(2R,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,4,10,12-tetramethylhexadeca-8,13-dien-3-ol 
• 3019-71-4 Trichloroacetyl isocyanate 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 154919-93-4 (S)-4-Benzyl-3-[(2S,3R)-6-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-hexanoyl]-oxazolidin-2-one 
• 479673-37-5 (2S)-2-[(4R,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propan-1-ol 
• 183565-25-5 (R)-4-Benzyl-3-[(2R,3S,4S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentanoyl]-oxazolidin-2-one 
• 479673-49-9 (4R,5R)-tert-butyl-{3-[2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane 
• 479673-36-4 (2S)-tert-butyl-{(4R,5S)-2-[2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane 
• 565229-78-9 (2S,3S,4S,5R,6R)-3-(6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl)propionaldehyde 
• 565229-75-6 (4R)-4-benzyl-3-[(2R,3S)-3-hydroxy-6-(4-methoxybenzyloxy)-2-methylhexanoyl]oxazolidin-2-one 
• 565229-47-2 (4S,5R)-4-{(3Z,5S,6S,7S,8Z)-6-(4-methoxybenzyloxy)-11-[(2S,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-5,7-dimethylundeca-3,8-dienyl}-2-(4-methoxyphenyl)-5-methyl[1,3]dioxane 
• 565229-51-8 (2S,3R,6Z,8S,9S,10S,11Z)-3,9-bis(4-methoxybenzyloxy)-14-[(2S,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,8,10-trimethyltetradeca-6,11-dienal 
• 565229-03-0 (4R)-4-benzyl-3-[(2R,3S,4R,5S)-5-(tert-butyldimethylsilanyloxy)-8-(4-methoxybenzyloxy)-3-methoxymethoxy-2,4-dimethyloctanoyl]oxazolidin-2-one 
• 565229-77-8 (4R)-4-benzyl-3-[(2R,3S,4R,5S)-5-(tert-butyldimethylsilanyloxy)-3-hydroxy-8-(4-methoxybenzyloxy)-2,4-dimethyloctanoyl]oxazolidin-2-one 

Downstream Products

• 565229-96-1 Carbamic acid (6Z,11Z)-(1S,2S,3R,8S,9R,10S)-1-isopropyl-3,9-bis-(4-methoxy-benzyloxy)-14-((2S,3R,4S,5R)-4-methoxymethoxy-3,5-dimethyl-6-oxo-tetrahydro-pyran-2-yl)-2,8,10-trimethyl-tetradeca-6,11-dienyl ester 

Relevant academic research and scientific papers

Simplified discodermolide analogues: Synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents

Several novel analogues of (+)-discodermolide were synthesized via a convergent strategy that used Wittig reactions to append left and right side chains to a central scaffold and then tested for biological activity. Three of the analogues in the 4-epi-7-d