5653-42-9

Basic information

• Product Name: 6,7-DiMethoxy-isochroMan-1,3-dione
• Synonyms: 6,7-DiMethoxy-isochroMan-1,3-dione;6,7-dimethoxy-1H-isochromene-1,3(4H)-dione;6,7-DIMETHOXY-1H-ISOCHROMENE-1,3(4H)-DIONE(WXG02926)
• CAS NO: 5653-42-9
• Molecular Formula: C₁₁H₁₀O₅
• Molecular Weight: 222.1941
• EINECS: 1312995-182-4
• Mol File: 5653-42-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 175 °C
• Boiling Point: 415.338 °C at 760 mmHg
• Flash Point: 189.164 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 4.16E-07mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 6,7-DiMethoxy-isochroMan-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DiMethoxy-isochroMan-1,3-dione(5653-42-9)
• EPA Substance Registry System: 6,7-DiMethoxy-isochroMan-1,3-dione(5653-42-9)

Safety Data

• Hazardous Substances Data: 5653-42-9(Hazardous Substances Data)

Usage

General Description

6,7-DiMethoxy-isochroMan-1,3-dione, also known as isochromanone, is a chemical compound with the molecular formula C11H12O4. It is a derivative of isochroman and is commonly used in organic synthesis as a building block for various pharmaceutical and agrochemical compounds. 6,7-DiMethoxy-isochroMan-1,3-dione has been studied for its potential biological activities, including antioxidant and anticancer properties. Its chemical structure and reactivity make it a valuable intermediate in the development of new drugs and agrochemicals. Additionally, it is used as a precursor for the synthesis of natural products and complex organic molecules. Overall, 6,7-DiMethoxy-isochroMan-1,3-dione is a versatile compound with diverse applications in the field of organic chemistry and drug discovery.

InChI:InChI=1/C11H10O5/c1-14-8-3-6-4-10(12)16-11(13)7(6)5-9(8)15-2/h3,5H,4H2,1-2H3

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 50-00-0 formaldehyd 
• 3808-98-8 5,6-dimethoxy-3-trichloromethyl-phthalide 
• 93-07-2 Veratric acid 
• 3808-99-9 2-(2,2-dichloro-ethyl)-4,5-dimethoxy-benzoic acid 
• 16135-41-4 6,7-dimethoxy-3,4-dihydro-1H-2-benzopyran-3-one 
• 3809-00-5 4,5-dimethoxyhomophthalic acid 

Downstream Products

• 84245-31-8 2,3-dimethoxy-5,7,11b,12-tetrahydro-isoindolo[2,1-b]isoquinoline 
• 84245-32-9 2,3,9,10-Tetramethoxy-5,7,11b,12-tetrahydro-isoindolo[2,1-b]isoquinoline 
• 37039-63-7 3t-benzo[1,3]dioxol-5-yl-6,7-dimethoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinoline-4r-carboxylic acid methyl ester 
• 477742-06-6 2-(2-hydrazino-2-oxoethyl)4,5-dimethoxy benzoic acid 
• 136390-03-9 2,3,10,11-tetraacetoxy-5,6-dihydro-8H-dibenzoquinolizin-8-one 
• 136390-02-8 3,10,11-triacetoxy-5,6-dihydro-8H-dibenzoquinolizin-8-one 

Relevant articles and documents

Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**

A complementary dual carbonyl activation strategy for the synthesis of polycyclic alkaloids has been developed. Successful applications include the synthesis of tetracyclic alkaloids harmalanine and harmalacinine, pentacyclic indoloquinolizidine alkaloid nortetoyobyrine, and octacyclic β-carboline alkaloid peganumine A. The latter synthesis features a protecting-group-free assembly and an asymmetric disulfonimide-catalyzed cyclization. Furthermore, formal syntheses of hirsutine, deplancheine, 10-desbromoarborescidine A, and oxindole alkaloids rhynchophylline and isorhynchophylline have been achieved. Finally, a concise synthesis of berberine alkaloid ilicifoline B was completed.

Synthesis of 3-Ferrocenyl Isocoumarins

The derivatives of 3-ferrocenyl isocoumarin were synthesized by the condensation of substituted homothphalic anhydride with ferrocene using phosphoric acid or anhydrous aluminium chloride as cyclising agent. Substituted homophthalic acid did not condense with ferrocene so homophthalic acids were converted into their anhydride and then allowed to react with ferrocene in the presence of polyphosphoric acid or in the presence of anhydrous aluminium chloride using dichloromethane as the solvent to give 3-ferrocenyl isocoumarins. 7-Methoxy, 6-methyl, 5,7-dihydroxy, 6,7-dimethoxy and 5,7-dimethoxy derivatives of 3-ferrocenyl isocoumarin were synthesized. All the compounds were characterised by melting point determination, elemental and spectral analysis.

NOVEL INHIBITORS OF FLAVIVIRUS REPLICATION

The present invention relates to a series of novel compounds, methods to prevent or treat viral infections by using the novel compounds, processes for preparation of the compounds, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Hepatitis C virus (HCV). The present invention also relates to the novel compounds for use as a medicine, more preferably for use as a medicine for the prevention or treatment of viral infections, preferably infections with viruses belonging to the family of the Flaviviridae.