5653-80-5

Basic information

• Product Name: S(+)-METHADONE HYDROCHLORIDE INACTIVE EN ANTIOMER O
• Synonyms: S(+)-METHADONE HYDROCHLORIDE INACTIVE EN ANTIOMER O;(s)-6-(dimethylamino)-4,4-diphenyl-3-heptanone;4-diphenyl-6-(dimethylamino)-(s)-3-heptanon;6s-methadone;d-6-(dimethylamino)-4,4-diphenyl-3-heptanone;dextromethadone;d-methadone;l-(+)-methadone
• CAS NO: 5653-80-5
• Molecular Formula: C₂₁H₂₇NO
• Molecular Weight: 309.44518
• Mol File: 5653-80-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 100.5°C
• Boiling Point: 449.71°C (rough estimate)
• Flash Point: 126.5°C
• Appearance: white/solid
• Density: 1.0350 (rough estimate)
• Vapor Pressure: 2.2E-07mmHg at 25°C
• Refractive Index: 1.5614 (estimate)
• Solubility: H2O: soluble
• PKA: 9.05±0.50(Predicted)
• CAS DataBase Reference: S(+)-METHADONE HYDROCHLORIDE INACTIVE EN ANTIOMER O(CAS DataBase Reference)
• NIST Chemistry Reference: S(+)-METHADONE HYDROCHLORIDE INACTIVE EN ANTIOMER O(5653-80-5)
• EPA Substance Registry System: S(+)-METHADONE HYDROCHLORIDE INACTIVE EN ANTIOMER O(5653-80-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-42/43
• Safety Statements: 22-26-36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: MJ6000000
• Hazardous Substances Data: 5653-80-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3/t17-/m0/s1

Upstream product

• 76-99-3 Methadone 
• 1095-90-5 methadone hydrochloride 
• 7576-08-1 (S)-(+)-2,2-diphenyl-4-dimethylaminopentanenitrile 
• 925-90-6 ethylmagnesium bromide 
• 125-79-1 (R,S)-2,2-diphenyl-4-dimethylaminopentanenitrile 

Downstream Products

• 15284-15-8 (+)-Methadone hydrochloride 

Relevant articles and documents

Simultaneous chiral separation of tramadol and methadone in tablets, human urine, and plasma by capillary electrophoresis using maltodextrin as the chiral selector

The stereoselective analysis and separation of racemic drugs play an important role in pharmaceutical industry to eliminate the unwanted isomer and find the right therapeutic control for the patient. Present study suggests a maltodextrin-modified capillary electrophoresis method for a single‐run chiral separation of two closely similar opiate pain relief drugs: tramadol (TRA) and methadone (MET). The best separation method possible for the both enantiomers was achieved on an uncoated fused‐silica capillary at 25°C using 100 mM phosphate buffer (pH 8.0) containing 20% (w v?1) maltodextrin with dextrose equivalent of 4–7 and an applied voltage of 16 kV. Under optimal conditions, the baseline resolution of TRA and MET enantiomers was obtained in less than 12 minutes. The relative standard deviations (n = 3) of 20 μg mL?1 TRA and MET were 2.28% and 3.77%, respectively. The detection limits were found to be 2 μg mL?1 for TRA and 1.5 μg mL?1 for MET. This method was successfully applied to the measurement of drugs concentration in their tablets, urine, and plasma samples.