56542-67-7

Basic information

• Product Name: 3-Cyanobenzene-1-sulfonyl chloride
• Synonyms: AKOS BB-9463;3-CYANOBENZENE-1-SULFONYL CHLORIDE;3-CYANOBENZENESULFONYL CHLORIDE;3-CYANOBENZENESULPHONYL CHLORIDE;BUTTPARK 33\11-95;3-Cyanobenzenesulfonylchlorid;3-Cyanobenzenesulphonyl chloride 98%;3-Cyanobenzene-1-sul
• CAS NO: 56542-67-7
• Molecular Formula: C₇H₄ClNO₂S
• Molecular Weight: 201.63
• EINECS: -0
• Product Categories: Phenyls & Phenyl-Het;Sulphonyl Chlorides;Benzenesulfonyl chloride;Phenyls & Phenyl-Het;Sulphonyl Chlorides;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Aromatics;Inhibitors;Sulfur & Selenium Compounds
• Mol File: 56542-67-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 49-53 °C(lit.)
• Boiling Point: 148 °C
• Flash Point: >230 °F
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moistute Sensitive
• BRN: 2832925
• CAS DataBase Reference: 3-Cyanobenzene-1-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyanobenzene-1-sulfonyl chloride(56542-67-7)
• EPA Substance Registry System: 3-Cyanobenzene-1-sulfonyl chloride(56542-67-7)

Safety Data

• Hazard Codes: C
• Statements: 34-43-20/21/22
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 56542-67-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 56542-67-7 differently. You can refer to the following data:
1. A benzenesulfonamide
2. A benzenesulfonamide derivative as potential kinase inhibitors.

InChI:InChI=1/C7H4ClNO2S/c8-12(10,11)7-3-1-2-6(4-7)5-9/h1-4H

Upstream product

• 4025-64-3 3-Carboxybenzenesulfonyl chloride 
• 2237-30-1 m-cyanoaniline 
• 636-76-0 3-sulfamoylbenzoic acid 

Downstream Products

• 3118-68-1 3-cyanobenzenesulfonamide 
• 56542-61-1 3-cyano-benzenesulfonic acid ethylamide 
• 597561-38-1 3-cyano-N,N-dimethylbenzenesulfonamide 
• 860515-67-9 3-cyano-benzenesulfonic acid diethylamide 
• 830331-53-8 C₁₇H₁₅ClF₃N₅O₃S 
• 197960-50-2 3-(3-cyanophenylsulfonyloxy)-5-methylphenol 
• 943742-56-1 N-(4-bromophenethyl)-3-cyanobenzenesulfonamide 
• 881678-96-2 3-({4-[(methylamino)methyl]-2-phenyl-1H-pyrrol-1-yl}sulfonyl)benzonitrile hydrochloride 
• 1053179-79-5 C₂₅H₂₆ClN₅O₅S 
• 1187966-55-7 3-cyano-N-[(2,3-diaza-spiro[4.4]non-3-en-2-yl)-ethylamino-methylene]-benzenesulfonamide 
• 1187966-54-6 3-cyano-N-[(4,4-dimethyl-4,5-dihydro-pyrazol-1-yl)-ethylamino-methylene]-benzenesulfonamide 
• 1015168-43-0 3-cyano-N-[ethylamino-(4-ethyl-4,5-dihydro-pyrazol-1-yl)-methylene]-benzenesulfonamide 
• 915762-41-3 N-(1-[(3-cyanophenyl)sulfonyl]piperidin-4-yl)-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide 
• 1196113-04-8 3-Cyano-N-(1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzenesulfonamide 

Relevant articles and documents

Preparation method of substituted benzene sulfonyl chloride

The invention provides a preparation method of substituted benzene sulfonyl chloride, which comprises the following steps: carrying out diazotization reaction on an aniline compound with a structure as shown in a formula I to obtain fluoboric acid diazonium salt with a structure as shown in a formula II; obtaining substituted benzene sulfonyl chloride with a structure as shown in a formula III from the fluoboric acid diazonium salt with the structure as shown in the formula II; wherein R is selected from any one of ortho-chlorine, bromine, methyl, chloromethyl, bromomethyl, nitro, cyano, acetyl, meta-chlorine, bromine, methyl, chloromethyl, bromomethyl, nitro, cyano, acetyl, para-chlorine, bromine, methyl, chloromethyl, bromomethyl, nitro, cyano and acetyl. The preparation method of the substituted benzene sulfonyl chloride provided by the invention is simple in reaction process, easy to operate, ideal in effect and suitable for industrial production.

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labour intensive way than the corresponding batch method.

Sulfonamide-containing indole compounds

The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof. In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1-C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1-C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded. Further, when the ring A is cyanophenyl group, 2-amino-5-pyridyl group or a 2-halo-5-pyridyl group and R1 is cyano group or a halogen atom, at least one of R2 and R3 should not be a hydrogen atom.