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1-isopentyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione, commonly known as thalidomide, is a synthetic derivative of glutamic acid with a complex molecular structure. Initially developed as a sedative and hypnotic medication, it gained notoriety for its teratogenic effects, causing severe birth defects when administered during pregnancy. Despite its controversial history, thalidomide has re-emerged as a valuable therapeutic agent due to its immunomodulatory and anti-inflammatory properties, making it a versatile compound in modern medicine.

565448-79-5

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565448-79-5 Usage

Uses

Used in Pharmaceutical Industry:
1-isopentyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione is used as an immunomodulatory and anti-inflammatory agent for the treatment of various conditions, including leprosy, multiple myeloma, and certain autoimmune diseases. Its ability to modulate the immune system and reduce inflammation makes it a valuable asset in managing these conditions.
Used in Oncology:
In the field of oncology, 1-isopentyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione is being investigated for its potential in treating various cancers. Its immunomodulatory properties may enhance the body's natural defense mechanisms against cancer cells, while its anti-inflammatory effects could help reduce tumor-promoting inflammation.
Used in HIV/AIDS Treatment:
1-isopentyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione is also being explored for its potential in treating HIV/AIDS. Its immunomodulatory effects may help improve the immune response in HIV-infected individuals, potentially leading to better disease management and improved quality of life.
Used in Inflammatory Disorders:
Due to its anti-inflammatory properties, 1-isopentyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione is being investigated for its potential in treating various inflammatory disorders. Its ability to reduce inflammation may help alleviate symptoms and improve the overall prognosis for patients suffering from these conditions.
Precautionary Measures:
As a teratogen, 1-isopentyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione requires strict measures to prevent its use during pregnancy or in women of childbearing potential without adequate contraception. The teratogenic effects of thalidomide have led to the implementation of stringent safety protocols to ensure its safe and responsible use in medical practice.

Check Digit Verification of cas no

The CAS Registry Mumber 565448-79-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,6,5,4,4 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 565448-79:
(8*5)+(7*6)+(6*5)+(5*4)+(4*4)+(3*8)+(2*7)+(1*9)=195
195 % 10 = 5
So 565448-79-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O3/c1-8(2)5-7-14-10-9(4-3-6-13-10)11(15)17-12(14)16/h3-4,6,8H,5,7H2,1-2H3

565448-79-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-methylbutyl)pyrido[2,3-d][1,3]oxazine-2,4-dione

1.2 Other means of identification

Product number -
Other names 1-(3-methylbutyl)-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:565448-79-5 SDS

565448-79-5Relevant academic research and scientific papers

Anti-infective agents

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Page 40, (2010/02/06)

Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Anti-infective agents

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Page/Page column 73, (2010/02/08)

The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HC

Anti-infective agents

-

, (2008/06/13)

Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

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