565450-03-5Relevant academic research and scientific papers
Novel synthesis of P-chiral hydroxymethylphosphine-boranes through lipase-catalyzed optical resolution
Shioji, Kosei,Kurauchi, Yoshimitsu,Okuma, Kentaro
, p. 833 - 834 (2003)
A novel approach toward the lipase-catalyzed acylation of alkyl(1-hydroxymethyl)phosphine-boranes was achieved. Up to 99% of enantiomerically enriched phosphine-boranes was obtained by using lipase AK and CAL.
Reduction of functionalized tertiary phosphine oxides with BH3
Sowa, Sylwia,Stankevi?, Marek,Szmigielska, Anna,Ma?uszyńska, Hanna,Kozio?, Anna E.,Pietrusiewicz, K. Micha?
, p. 1672 - 1688 (2015/02/19)
A direct stereoselective conversion of tertiary hydroxyalkylphosphine oxides to the corresponding tertiary hydroxyalkylphosphine-boranes involving facile reduction of the P=O bond by BH3 under mild conditions has been developed. The unprecedented facility of reduction of the strong P=O bond by BH3, a mild reducing agent, has been achieved through an intramolecular P=O···B complexation directed by proximal aα- or β-hydroxy groups present in the phosphine oxide structures. As established by two chemical correlations, the developed transformation of hydroxyalkylphosphine oxides into hydroxyalkylphosphine-boranes takes place with complete inversion of configuration at P.
