565469-65-0

Upstream product

• 870526-97-9 (4E,8E)-2-(Benzhydrylidene-amino)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid ethyl ester 
• 24163-93-7 farnesyl bromide 
• 39021-62-0 1-methylimidazole-5-carbaldehyde 
• 638132-07-7 (4E,8E)-2-[Benzenesulfonyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid ethyl ester 
• 565469-64-9 (4E,8E)-5,9,13-Trimethyl-2-[(3-methyl-3H-imidazol-4-ylmethyl)-amino]-tetradeca-4,8,12-trienoic acid ethyl ester 

Downstream Products

• 638132-08-8 (S)-2-{(4E,8E)-2-[Benzenesulfonyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino}-3-phenyl-propionic acid methyl ester 

Relevant academic research and scientific papers

From pure FPP to mixed FPP and CAAX competitive inhibitors of farnesyl protein transferase

Starting from a FPP analogue with nanomolar inhibitory activity against isolated FPTase, yet lacking activity in cellular assays, structural modifications were performed to enhance cellular activity by removing all acidic functionalities. Overall, these changes resulted in the transformation of a pure FPP to a mixed FPP and CAAX competitive inhibitor with nanomolar activity on isolated FPTase and micromolar inhibitory activity in the farnesylation of H-Ras in cultured DLD-1 cells.