56554-94-0Relevant academic research and scientific papers
An efficient conversion of carboxylic acids to one-carbon degraded aldehydes via 2-hydroperoxy acids
Akakabe, Yoshihiko,Nyuugaku, Takeshi
, p. 1370 - 1371 (2008/02/07)
After the formation of dianions of a carboxylic acid with lithium diisopropylamide, oxygen was bubbled into the solution to produce 2-hydroperoxy acid. Then the reaction mixture was acidified with a 2N HCl solution and subsequently elevated to 50°C to afford the aldehyde with the loss of one carbon atom. Even saturated (C10-C20) and unsaturated (C18:1) carboxylic acids were converted into the odd aldehydes (C9-C19, C17:1) in high yields. This conversion was found to be an efficient method for the preparation of carboxylic acids (Cn) to one-carbon degraded aldehydes (Cn-1) via 2-hydroperoxy acids.
