56563-00-9

Basic information

• Product Name: 2-(1H-imidazol-1-yl)acetohydrazide(SALTDATA: HCl)
• Synonyms: 2-(1H-imidazol-1-yl)acetohydrazide(SALTDATA: HCl);2-(1H-imidazol-1-yl)acetohydrazide hydrochloride
• CAS NO: 56563-00-9
• Molecular Formula: C₅H₈N₄O
• Molecular Weight: 140.14
• Mol File: 56563-00-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1H-imidazol-1-yl)acetohydrazide(SALTDATA: HCl)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-imidazol-1-yl)acetohydrazide(SALTDATA: HCl)(56563-00-9)
• EPA Substance Registry System: 2-(1H-imidazol-1-yl)acetohydrazide(SALTDATA: HCl)(56563-00-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 56563-00-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(1H-imidazol-1-yl)acetohydrazide(SALTDATA: HCl) is used as a pharmaceutical agent for its potential anticonvulsant properties, which can help in the management and treatment of seizure disorders. Its antihypertensive effects also make it a candidate for the development of medications aimed at treating high blood pressure.
Used in Organic Synthesis:
In the field of organic chemistry, 2-(1H-imidazol-1-yl)acetohydrazide(SALTDATA: HCl) serves as a valuable intermediate in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with different applications in various industries.
Further research is necessary to fully understand the medicinal and chemical properties of 2-(1H-imidazol-1-yl)acetohydrazide(SALTDATA: HCl), which could lead to additional applications and uses in the future.

Upstream product

• 17450-34-9 ethyl 2-(1H-imidazol-1-yl)acetate 

Downstream Products

• 219647-65-1 Imidazol-1-yl-acetic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 219647-61-7 N¹(phenylidenehydrazido methyl)-imidazole 
• 219647-75-3 2-imidazol-1-yl-N-[2-(4-nitro-phenyl)-4-oxo-thiazolidin-3-yl]-acetamide 
• 219647-74-2 2-imidazol-1-yl-N-[2-(2-nitro-phenyl)-4-oxo-thiazolidin-3-yl]-acetamide 
• 219647-76-4 N-[2-(4-dimethylamino-phenyl)-4-oxo-thiazolidin-3-yl]-2-imidazol-1-yl-acetamide 
• 219647-72-0 2-imidazol-1-yl-N-[2-(2-methoxy-phenyl)-4-oxo-thiazolidin-3-yl]-acetamide 
• 219647-70-8 N-[2-(2-chloro-phenyl)-4-oxo-thiazolidin-3-yl]-2-imidazol-1-yl-acetamide 
• 219647-73-1 2-imidazol-1-yl-N-[2-(4-methoxy-phenyl)-4-oxo-thiazolidin-3-yl]-acetamide 
• 219647-71-9 N-[2-(4-chloro-phenyl)-4-oxo-thiazolidin-3-yl]-2-imidazol-1-yl-acetamide 
• 219647-69-5 2-phenyl-3(N¹-imidazolyl-acetamidyl)-4-oxo-thiazolidine 
• 219647-66-2 Imidazol-1-yl-acetic acid [1-(2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 219647-63-9 Imidazol-1-yl-acetic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 219647-68-4 Imidazol-1-yl-acetic acid [1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazide 
• 219647-67-3 Imidazol-1-yl-acetic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 

Relevant articles and documents

7-OXO -6-(SULFOOXY)- 1,6-DIAZABICYCLO [3.2.1] OCTANE CONTAINING COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS

Compounds of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, their preparation, and use in treating a bacterial infection are disclosed.

Tetrazolylhydrazides as selective fragment-like inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A

The JumonjiC-domain-containing histone demethylase 2A (JMJD2A, KDM4A) is a key player in the epigenetic regulation of gene expression. Previous publications have shown that both elevated and lowered enzyme levels are associated with certain types of cancer, and therefore the definite role of KDM4A in oncogenesis remains elusive. To identify a novel molecular starting point with favorable physicochemical properties for the investigation of the physiological role of KDM4A, we screened a number of molecules bearing an iron-chelating moiety by using two independent assays. In this way, we were able to identify 2-(1H-tetrazol-5-yl)acetohydrazide as a novel fragment-like lead structure with low relative molecular mass (Mr=142 Da), low complexity, and an IC50 value of 46.6 μm in a formaldehyde dehydrogenase (FDH)-coupled assay and 2.4 μm in an antibody-based assay. Despite its small size, relative selectivity against two other demethylases could be demonstrated for this compound. This is the first example of a tetrazole group as a warhead in JMJD demethylases. Anchor fragment: To develop non-promiscuous metalloenzyme inhibitors, a metal-complexing acetohydrazide group was integrated in a tetrazolyl fragment, which can be matured into a scaffold to promote further selectivity at the ligand backbone binding site of these emerging drug targets.

Synthesis and biological activity of 2-(substituted aryl)-3- (N1-imidazolyl-acetamidyl)-4-oxo-thiazolidines and their 5-arylidine derivatives

Several 2-(substituted aryl)-3-(N 1-imidazolylacetamidyl)-4-oxo-thiazolidines 4 and 2-(substituted aryl, -3-(N 1-imidazolylacetamidyl)-5-arylidine-4-oxothiazolidines 5 have been synthesised and tested for their biological activity. Their structures have been elucidated on the basis of their elemental analysis and spectral data.