56570-36-6

Upstream product

• 106-47-8 4-chloro-aniline 
• 123-54-6 acetylacetone 

Downstream Products

• 1116686-34-0 9-acetyl-4-benzoyl-7-(4-chlorophenyl)-3-hydroxy-1-(2-hydroxyphenyl)-8-methyl-1,7-diazaspiro[4.4]nona-3,8-diene-2,6-dione 
• 1116686-36-2 9-acetyl-7-(4-chlorophenyl)-3-hydroxy-1-(2-hydroxyphenyl)-4-(4-methoxybenzoyl)-8-methyl-1,7-diazaspiro[4.4]nona-3,8-diene-2,6-dione 
• 86067-03-0 N-(4-Chlorphenyl)-4-(trimethylsiloxy)-3-penten-2-imin 
• 54196-36-0 (Z)-4-(4-Chloro-phenylamino)-pent-3-ene-2-thione 

Relevant academic research and scientific papers

Solvent-free synthesis of β-enamino ketones and esters catalysed by recyclable iron(III) triflate

A novel application of highly stable Fe(OTf)3 as an efficient catalyst for the synthesis of a variety of β-enamino ketones and esters under solvent-free conditions is described. Notably, this protocol of a "green synthesis", which produced β-enamino ketones and esters by the reaction of a variety of β-dicarbonyl compounds and primary amines, exhibits attractive properties including high yields, short reaction periods, lower loading of catalyst and chemo- and regio-selectivity. In addition, the catalyst was easily recovered from the reaction system and readily reused with minimal loss of activity.

Ferric nitrate nonahydrate as a mild and efficient catalyst for the synthesis of ss-enaminones

Ferric nitrate nonahydrate (Fe(NO3)3 -9H 2O) has been found to be an extremely mild and efficient catalyst for the preparation of ss-enaminones from ss-dicarbonyl compounds and amines (aliphatic amines, aromatic amines and

Formic acid: A low-cost, mild, ecofriendly, and highly efficient catalyst for the rapid synthesis of β-enaminones

β-Enaminones have been synthesized by the condensation reaction of b-diketones with various anilines in the presence of a catalytic amount of formic acid, mild and highly efficient acid catalyst in methanol. These condensation reactions proceed smoothly in short reaction times with near-quantitative yields. Copyright

Zinc triflate catalysed synthesis of β-enamino ketones(esters) under solvent-free conditions

An efficient and mild procedure is described for the synthesis of a series of β-enamino ketones(esters) from 1,3-dicarbonyl compounds and aliphatic and aromatic amines using zinc triflate as the catalyst.

A general and efficient method for synthesis of enaminones and enamino esters catalyzed by NbCl5 under solvent-free conditions

A general and simple procedure was developed for the synthesis of β-enaminones and β-enamino esters by reacting 1,3-dicarbonyl compounds with amines in the presence of catalytic amounts of niobium pentachloride. The reaction proceeds smoothly at room temperature under solvent-free conditions and leads to chemo- and regioselective formation of enamine derivatives in high to excellent yields.

Silica supported Fe(HSO4)3 as an efficient, heterogeneous and recyclable catalyst for synthesis of β-enaminones and β-enamino esters

A series of β-substituted enaminones were prepared through the one-pot reaction of β-dicarbonyl compounds with various amines in the presence of silica ferric hydrogensulfate under solvent free conditions at room temperature. The reactions proceed smoothl

Approach to synthesis of Β-enamino ketones and pyrroles catalyzed by gallium(III) triflate under solvent-free conditions

Metal triflates have been used to catalyze synthesis of-enamino ketones or pyrroles from amines and 1,3-dicarbonyl or 1,4-dicarbonyl compounds under solvent-free conditions, respectively. Among different metal triflates screened, 0.5mol% Ga(OTf)3 efficiently promoted the reactions to give excellent yields. In addition, the catalyst could be recovered easily after the reactions and reused without evident loss in activity.

Room-temperature synthesis of pyrazoles, diazepines, β-enaminones, and β-enamino esters using silica-supported sulfuric acid as a reusable catalyst under solvent-free conditions

Silica-supported sulfuric acid (H2SO4·SiO2) has been utilized as a heterogeneous recyclable catalyst for a highly efficient regio- and chemoselective condensation of hydrazines/hydrazides, diamines, and primary amines with various β-dicarbonyl compounds at room temperature to afford pyrazoles, diazepines, and β-enaminones/β-enamino esters under solvent-free conditions within 5-15 min. Copyright Taylor & Francis Group, LLC.

Synthesis of pyrazoles, diazepines, enaminones, and enamino esters using 12-tungstophosphoric acid as a reusable catalyst in water

12-Tungstophosphoric acid (H3PW12O40) is found to be an efficient and recyclable catalyst in promoting a chemo- and regioselective condensation of hydrazines/hydrazides, diamines, and primary amines with various 1,3-dicarbonyl compounds in pure water at room temperature to afford pyrazoles, diazepines, and enaminones/enamino esters, respectively, in high yields. Georg Thieme Verlag Stuttgart.

A mild method for the synthesis of β-enaminones and β-enamino esters using KH2P04 as catalyst

β-Enaminones and β-enamino esters have been produced by the direct condensation of amines with β-diketones and β-ketoesters using KH2P04 as catalyst under mild, solvent-free conditions.