56575-49-6

Usage

Physical state

Colorless liquid at room temperature

Odor

Strong ammonia-like odor

Solubility

Highly soluble in water

Uses

a. Curing agent for epoxy resins and polyurethane materials
b. Hardener or cross-linking agent in various applications
c. Production of adhesives and coatings
d. Corrosion inhibitor in water treatment processes
e. Manufacturing of rubber and plastics
f. Pharmaceutical industry for the synthesis of certain medications

Safety precautions

Handle and store with care to prevent exposure and potential hazards

Upstream product

• 35980-65-5 1,4,7-tri(p-toluenesulfonyl)-1,4,7-triazacyclodecane 

Relevant academic research and scientific papers

Synthesis of azamacrocycles via a Mitsunobu reaction

Reaction of pernosylated diethylenetriamine and 2-substituted propane-1,3-diols in dry THF in the presence of triphenylphosphine and diisopropyl azodicarboxylate gives the corresponding protected 9-substituted 1,4,7-triazacyclodecanes. The Mitsunobu reaction was also used in the preparation of 3-substituted 1,5,9-triazacyclododecanes and macrocyclic pyridine derivatives.

Synthesis of a series of triaza-macrocyclicanes

Condensation of the N, N′, N″-tris(p-toluenesulfonyl)diethylenetrimine-N,N″-disodium with bissulphonate esters of two-, three-, four- and six-carbon diols gives the corresponding 9-, 10-,11-, 13-membered triamine macrocycles containing N-ptoluenesulfonyl group, respectively. The p-tuluenesulfonyl groups are removed with concentrated sulfuric acid, acetic acidhydrobromic acid or LiAlH4 which give the ammonium salts of 1,4,7-triazacyclononane, 1,4,7-triazacyclodecane, 1,4,7-triazacycloundecane, 1,4,7-triazacyclotridecane, respectively. Comparison and details of the different synthetic procedures of the triamine macrocycles are described as well.

SYNTHESIS AND COPPPER(I) COMPLEXES OF A SERIES OF 9- TO 13-MEMBERED N3 MACROCYCLES

Eight cyclic triamines with ring sizes between 9 and 13 were synthesized by the p-toluenesulfonate method.The open-chain triamines bis(2-aminoethyl)amine (dien) and bis(3-aminopropyl)amine (diprop) were used as starting materials.In some cases, the corresponding dimeric cyclic hexaamines have been isolated and characterized as major by-products.The complexation of Cu(I) by the triamines has been studied potenciometrically in CH3CN/H2O.All ligands L form ternary complexes .The corresponding association constants vary between 1E11 and 1E7, decreasing with increasing ring size.In addition , complexes yLH>(2+), y= 1 or 2, are found as less important species with maximum concentrations of 7 to 50 percent.