56576-40-0Relevant articles and documents
Anthranilic acid replacements in a niacin receptor agonist
Schmidt, Darby,Smenton, Abigail,Raghavan, Subharekha,Shen, Hong,Ding, Fa-Xiang,Carballo-Jane, Ester,Luell, Silvi,Ciecko, Tanya,Holt, Tom G.,Wolff, Michael,Taggart, Andrew,Wilsie, Larissa,Krsmanovic, Mihajlo,Ren, Ning,Blom, Daniel,Cheng, Kang,McCann, Peggy E.,Waters, M.Gerard,Tata, James,Colletti, Steven
scheme or table, p. 3426 - 3430 (2010/08/07)
Niacin is an effective drug for raising HDL cholesterol. However, niacin must be taken in large doses and significant side effects are often observed, including facial flushing, loss of glucose tolerance, and liver toxicity. An anthranilic acid was identified as an agonist of the niacin receptor. In order to improve efficacy and provide structural diversity, replacements for the anthranilic acid were investigated and several compounds with improved properties were identified.
Direct catalytic asymmetric enolexo aldolizations
Pidathala, Chandrakala,Hoang, Linh,Vignola, Nicola,List, Benjamin
, p. 2785 - 2788 (2007/10/03)
32 years after the first, and still the only, catalytic asymmetric intramolecular aldol reaction was published in this journal, the proline-catalyzed Hajos-Parrish-Eder-Sauer-Wiechert reaction is extended for the first time to catalytic asymmetric enolexo
Total regiospecific synthesis of the selagine tricyclic ring system
Gravel, D.,Bordeleau, L.,Ladouceur, G.,Rancourt, J.,Thoraval, D.
, p. 2945 - 2947 (2007/10/02)
Starting from 4-methylcyclohexanone, a total synthesis of the selagine tricyclic ring system is described in which complete control of regiospecificity is achieved in the elaboration of functionality.
