56579-87-4Relevant academic research and scientific papers
Pyrrolidine-linker-camphor assembly: Bifunctional organocatalysts for efficient Michael addition of cyclohexanone to nitroolefins under neat conditions
Anwar, Shaik,Lee, Pei-Hsun,Chou, Tsai-Yung,Chang, Chihliang,Chen, Kwunmin
, p. 1171 - 1177 (2011)
A simple and convenient strategy was developed to synthesize a new class of pyrrolidinyl-camphor based bifunctional organocatalysts possessing varying functional linkers. Catalytic screening of these camphor-pyrrolidine linked derivatives for asymmetric M
Asymmetric conjugate additions of carbonyl compounds to nitroalkenes under solvent-free conditions using fluorous diaminomethylenemalononitrile organocatalyst
Hirashima, Shin-Ichi,Narushima, Takafumi,Kawada, Masahiro,Nakashima, Kosuke,Hanai, Kaori,Koseki, Yuji,Miura, Tsuyoshi
, p. 1185 - 1190 (2018/05/02)
The novel fluorous organocatalyst bearing a diaminomethylenemalononitrile motif is prepared. The fluorous organocatalyst efficiently promotes asymmetric conjugate additions of ketones to nitroalkenes and results in high yields of these addition products with excellent enantioselectivities under solvent-free conditions.
Organocatalyzed asymmetric Michael addition by an efficient bifunctional carbohydrate-thiourea hybrid with mechanistic DFT analysis
Azad, Chandra S.,Khan, Imran A.,Narula, Anudeep K.
supporting information, p. 11454 - 11461 (2016/12/18)
A series of thiourea based bifunctional organocatalysts having d-glucose as a core scaffold were synthesized and examined as catalysts for the asymmetric Michael addition reaction of aryl/alkyl trans-β-nitrostyrenes over cyclohexanone and other Michael donors having active methylene. Excellent enantioselectivities (0. The obtained results were explained through DFT calculations using the B3LYP/6-311G(d,p)//B3LYP/6-31G(d) basic set. The QM/MM calculations revealed the role of cyclohexanone as a solvent as well as reactant in the rate determining step imparting 31.91 kcal mol?1 of energy towards the product formation.
Pyrrolidine-diaminomethylenemalononitrile organocatalyst for Michael additions of carbonyl compounds to nitroalkenes under solvent-free conditions
Nakashima, Kosuke,Hirashima, Shin-Ichi,Kawada, Masahiro,Koseki, Yuji,Tada, Norihiro,Itoh, Akichika,Miura, Tsuyoshi
, p. 2703 - 2706 (2014/05/06)
The novel pyrrolidine-diaminomethylenemalononitrile organocatalyst 7 promotes the asymmetric conjugate addition of a carbonyl compound to a nitroalkene to afford the corresponding adduct in high yield with up to 99% ee, under solvent-free conditions.
Highly enantioselective Michael addition reactions in water catalyzed by an insoluble MPS-supported 4-sulfonamidyl prolinol tert-butyldiphenylsilyl ether
Chuan, Yongming,Chen, Guihua,Peng, Yungui
supporting information; scheme or table, p. 3054 - 3058 (2009/10/11)
The development of a highly efficient, insoluble, and non-swelling MPS-supported organocatalyst for the direct asymmetric Michael reaction of ketones and aldehydes to nitrostyrenes at room temperature in water is described. Excellent yields (up to 100%) a
