56585-21-8Relevant academic research and scientific papers
Cooperative organocatalysis for the asymmetric γ alkylation of α-branched enals
Bergonzini, Giulia,Vera, Silvia,Melchiorre, Paolo
supporting information; experimental part, p. 9685 - 9688 (2011/03/16)
α Branched leads to γ: The direct and enantioselective γ alkylation of α-substituted α,β-unsaturated aldehydes under dienamine catalysis has been achieved. A cooperative catalysis system that involves dienamine activation of α-branched enals and chiral Bronsted acid catalysis promotes an SN1-alkylation pathway while ensuring complete γ-site selectivity and high stereocontrol (see scheme; Bn=benzyl). Copyright
