566199-90-4

Upstream product

• 58577-87-0 O-benzyl-L-serinol 
• 76679-39-5 [(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl trifluoromethanesulfonate 
• 22323-80-4 (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 

Downstream Products

• 566199-91-5 ((R)-2-Benzyloxy-1-hydroxymethyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 566199-93-7 ((S)-2-Benzyloxy-1-formyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 566199-94-8 (1S,4S,5R)-4-Benzyloxymethyl-6,8-dioxa-3-aza-bicyclo[3.2.1]octane-3-carboxylic acid 9H-fluoren-9-ylmethyl ester 

Relevant academic research and scientific papers

A new bicyclic proline-mimetic amino acid

A new constrained bicyclic α-amino acid proline-mimetic was developed. The synthesis was achieved starting from derivatives of the chiral pool, thus allowing to prepare analogues of either L- or D-proline by choosing appropriate stereoisomers of serine and α,β-isopropylidene-glycerol derivatives. The scaffolds were prepared as N-Fmoc-amino acid suitable for solid-phase peptide synthesis.