5662-95-3

Usage

Uses

Used in Pharmaceutical Industry:
3,3-Tetramethyleneglutaric anhydride is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3,3-Tetramethyleneglutaric anhydride serves as a versatile reagent for the preparation of a wide range of organic compounds. Its anhydride functionality can be utilized in various chemical reactions, making it a valuable asset in the synthesis of complex molecules.
Used in Research and Development:
Due to its unique properties and potential applications, 3,3-Tetramethyleneglutaric anhydride is also used in research and development for the exploration of new chemical reactions and the discovery of novel compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C9H12O3/c10-7-5-9(3-1-2-4-9)6-8(11)12-7/h1-6H2

Upstream product

• 16713-66-9 1,1-cyclopentanediacetic acid 
• 42940-56-7 7,9-dioxo-8-azaspiro[4.5]decane-6,10-dicarbonitrile 
• 861616-96-8 cyclopentylidenedi-malonic acid 
• 861342-71-4 [1-(carbamoyl-carboxy-methyl)-cyclopentyl]-malonic acid 

Downstream Products

• 77261-42-8 8-p-Tolyl-8-aza-spiro[4.5]decane-7,9-dione 
• 77261-44-0 8-(4-Chloro-phenyl)-8-aza-spiro[4.5]decane-7,9-dione 
• 77261-47-3 4-(7,9-Dioxo-8-aza-spiro[4.5]dec-8-yl)-benzoic acid 
• 77261-46-2 2-(7,9-Dioxo-8-aza-spiro[4.5]dec-8-yl)-benzoic acid 
• 403481-48-1 5-(4-methoxyphenyl)-5-oxo-3,3-tetramethylenepentanoic acid 
• 77274-96-5 8-(4-Nitro-phenyl)-8-aza-spiro[4.5]decane-7,9-dione 
• 77261-48-4 1-(7,9-Dioxo-8-aza-spiro[4.5]dec-8-yl)-3-phenyl-urea 
• 77261-67-7 8-Phenyl-8-aza-spiro[4.5]decane 
• 77261-39-3 8-Phenyl-8-aza-spiro[4.5]decane-7,9-dione 
• 77261-43-9 8-(3-Chloro-phenyl)-8-aza-spiro[4.5]decane-7,9-dione 
• 77261-41-7 8-m-Tolyl-8-aza-spiro[4.5]decane-7,9-dione 
• 77274-95-4 8-(3-Nitro-phenyl)-8-aza-spiro[4.5]decane-7,9-dione 
• 77261-40-6 8-o-Tolyl-8-aza-spiro[4.5]decane-7,9-dione 
• 77261-38-2 8-benzyl-8-azaspiro[4.5]decane-7,9-dione 

Relevant academic research and scientific papers

VITRIFIED STATE STABILIZING AGENT FOR ANIMAL CELL CRYOPRESERVATION SOLUTION

Provided are a vitrification stabilizer for animal cell cryopreservation fluid, and an animal cell cryopreservation fluid that exhibits superior vitrification capacity due to containing said vitrification stabilizer for animal cell cryopreservation fluid. The vitrification stabilizer for animal cell cryopreservation fluid contains an amphoteric polymer compound selected from the group consisting of: (a) an amphoteric polymer compound obtained by reacting ?-poly-L-lysine with butyl succinic acid anhydride and performing carboxylation; (b) an amphoteric polymer compound obtained by reacting ?-poly-L-lysine with butyl succinic acid anhydride and succinic acid anhydride, and performing carboxylation; and (c) an amphoteric polymer compound obtained by reacting ?-poly-L-lysine with a compound represented by formula (I) and performing carboxylation.

Antiproliferative and antibacterial activity of some glutarimide derivatives

Antiproliferative and antibacterial activities of nine glutarimide derivatives (1–9) were reported. Cytotoxicity of compounds was tested toward three human cancer cell lines, HeLa, K562 and MDA-MB-453 by MTT assay. Compound 7 (2-benzyl-2-azaspiro[5.11]heptadecane-1,3,7-trione), containing 12-membered ketone ring, was found to be the most potent toward all tested cell lines (IC50 = 9–27 μM). Preliminary screening of antibacterial activity by a disk diffusion method showed that Gram-positive bacteria were more susceptible to the tested compounds than Gram-negative bacteria. Minimum inhibitory concentration (MIC) determined by a broth microdilution method confirmed that compounds 1, 2, 4, 6–8 and 9 inhibited the growth of all tested Gram-positive and some of the Gram-negative bacteria. The best antibacterial potential was achieved with compound 9 (ethyl 4-(1-benzyl-2,6-dioxopiperidin-3-yl)butanoate) against Bacillus cereus (MIC 0.625 mg/mL; 1.97 × 10?3mol/L). Distinction between more and less active/inactive compounds was assessed from the pharmacophoric patterns obtained by molecular interaction fields.

Bronsted base-assisted boronic acid catalysis for the dehydrative intramolecular condensation of dicarboxylic acids

Bronsted base-assisted boronic acid catalysis for the dehydrative self-condensation of carboxylic acids is described. Arylboronic acid bearing bulky (N,N-dialkylamino)methyl groups at the 2,6-positions can catalyze the intramolecular dehydrative condensation of di-and tetracarboxylic acids. This is the first successful method for the catalytic dehydrative self-condensation of carboxylic acids.(Figure Presented)

METHOD FOR PRODUCING CARBOXYLIC ANHYDRIDE AND ARYLBORONIC ACID COMPOUND

When phthalic acid is heated in heptane under azeotropic reflux conditions in the presence of a catalytic amount of an arylboronic acid compound (such as 2,6-(diisopropylaminomethyl)phenylboronic acid or 2,6-bis(diisopropylaminomethyl)phenylboronic acid), phthalic anhydride is obtained in high yield.