566200-96-2

Upstream product

• 426219-35-4 6-bromo-N-methyl-2-naphthamide 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 5773-80-8 6-bromo-2-naphthoic acid 

Downstream Products

• 566200-78-0 ethyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl)-3-(1-trityl-1H-imidazol-4-yl)propanoate 
• 566939-85-3 Orteronel 
• 426219-18-3 orteronel 
• 566200-77-9 6-[1,3-dihydroxy-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide 
• 566200-98-4 tert-butyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate 
• 337521-39-8 N-methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide 

Relevant academic research and scientific papers

PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES

The present invention provides an advantageous production method of an imidazole derivative, which is suitable for industrial production. Compound (VI) is produced by reacting compound (I) with a Grignard reagent or a magnesium reagent, and a lithium reagent, and then reacting the resulting compound with compound (V).

PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME

The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I): and a Reformatsky reagent in a stable form suitable for the process.In the present invention, a compound represented by the general formula (I) is produced by reducing a specific β-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5 or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5·THF)2.