56621-48-8

Basic information

• Product Name: 1-(4-Hydroxyphenyl)piperazine
• Synonyms: 1-(4-Hydroxyphenyl)piperazine, 98% 5GR;1-(4-Hydrpxyphenyl)piperzine;4-(Piperazin-1-yl)phenol 98%;1-(4-Hydroxyphenyl)piperazine >=98.0% (NT);N-(4-Hydroxyphenyl) piperazine 1-(4-Hydroxyphenyl) piperazine;SALOR-INT L497754-1EA;RARECHEM AH CK 0119;N-(4-HYDROXYPHENYL)PIPERAZINE
• CAS NO: 56621-48-8
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• EINECS: 260-289-6
• Product Categories: Piperazines;PIPERIDINE;Nitrogen cyclic compounds;Piperidines, Piperidones, Piperazines;pharmacetical
• Mol File: 56621-48-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 220 °C
• Boiling Point: 371.3 °C at 760 mmHg
• Flash Point: 178.3 °C
• Appearance: Brownish/Powder
• Density: 1.141 g/cm³
• Vapor Pressure: 4.89E-06mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Store below +30°C.
• PKA: 12.18±0.30(Predicted)
• BRN: 150964
• CAS DataBase Reference: 1-(4-Hydroxyphenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Hydroxyphenyl)piperazine(56621-48-8)
• EPA Substance Registry System: 1-(4-Hydroxyphenyl)piperazine(56621-48-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN3263
• WGK Germany: 3
• F: 10-34
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 56621-48-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H14N2O/c13-10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2

Upstream product

• 38212-30-5 4-(4-methoxyphenyl)piperazine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 123-30-8 4-amino-phenol 
• 144881-52-7 1-(4-benzyloxyphenyl)piperazine 
• 943035-30-1 4-(4-benzyloxyphenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 7700-27-8 4-chlorophenyl benzyl ether 
• 106-48-9 4-chloro-phenol 
• 111-42-2 2,2'-iminobis[ethanol] 
• 110-85-0 piperazine 
• 106-41-2 4-bromo-phenol 
• 16712-16-6 ammonium formate 
• 321132-21-2 1-(4-benzyloxyphenyl)-piperazine hydrochloride 

Downstream Products

• 105746-19-8 4-(4-pentylpiperazino)phenol 
• 133345-21-8 1-(4-Acetoxyphenyl)-4-acetylpiperazine 
• 913734-86-8 2-[4-(4-hydroxyphenyl)piperazin-1-ylmethyl]indole-5-carbonitrile 
• 65277-42-1 ketoconazole 
• 67914-60-7 N-acetyl-N'-(4-hydroxyphenyl)piperazine 
• 913734-75-5 1-(4-(2-fluoroethoxy)phenyl)piperazine 
• 110645-24-4 (7S,8R)-2,7-Dihydroxy-8-{3-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-propyl}-7,8-dihydro-6H-5-oxa-9-thia-benzocycloheptene-8-carboxylic acid methyl ester 
• 132786-13-1 4-[4-(2-Amino-4,5-dihydro-oxazol-5-ylmethyl)-piperazin-1-yl]-phenol 
• 1026527-80-9 4-(4-Oxiranylmethyl-piperazin-1-yl)-phenol 

Relevant articles and documents

Alkaline Phosphatase Assay Based on the Chromogenic Interaction of Diethanolamine with 4-Aminophenol

Diethanolamine (DEA) has been extensively utilized as an alkaline buffer in current assays of alkaline phosphatase (ALP) activity in the past decades. While playing the role of a buffer, the chemical reactivity of DEA has been widely ignored in such assays. Herein, we report an interesting chromogenic interaction between DEA and 4-aminophenol (AP) in the presence of H2O for the first time, which inspires us to develop a novel DEA-participated ALP activity assay by using 4-aminophenyl phosphate (APP) as a substrate. This APP/DEA-based colorimetric approach has been proved to be comparable and even superior to the conventional p-nitrophenyl phosphate (pNPP)-based one, especially in the low ALP activity region, due to its higher sensitivity. The clear response mechanism and excellent sensing performance ensure that it can be further applied to determining ALP activity in real biological samples, screening potential ALP inhibitors in vitro, establishing ALP-enabled ELISA, and even fluorophore-assisted fluorescent ALP activity assay. It is demonstrated that this strategy not only possesses a good feasibility, but also exhibits a promising outlook for a series of ALP-related and -extended detections.

MALIC ENZYME INHIBITORS

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

Fast deprotection of phenoxy benzyl ethers in transfer hydrogenation assisted by microwave

Phenoxy benzyl ethers are easily and quickly deprotected in the presence of ammonium formate and microencapsulated Pd(0)EnCat with the assistance of microwave irradiation. This procedure can be applied in the presence of other functional groups as well. The described protocol is particularly convenient for the preparation in a parallel and automatic fashion of libraries of compounds possessing a phenol type moiety.