5663-38-7

Usage

General Description

1,3-Dioxane, 2-(3-methylphenyl)- is a chemical compound primarily used in the production of pharmaceuticals, dyes, and perfumes. It is a colorless liquid with a sweet odor and is commonly found in industrial settings as a solvent and a stabilizer for chlorinated solvents. This chemical has been linked to potential health risks, as it is classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC). Exposure to 1,3-Dioxane, 2-(3-methylphenyl)- can occur through inhalation, ingestion, or skin contact, and individuals should take caution when handling products containing 1,3-Dioxane, 2-(3-methylphenyl)-. Additionally, efforts are being made to reduce or eliminate the presence of 1,3-Dioxane, 2-(3-methylphenyl)- in consumer products and industrial processes to minimize potential health and environmental hazards.

Upstream product

• 17887-80-8 1,3-bis(trimethylsiloxy)propane 
• 620-23-5 m-tolyl aldehyde 

Relevant academic research and scientific papers

N-bromosuccinimide (NBS) catalyzed highly chemoselective acetalization of carbonyl compounds using silylated diols and pentaerythritol under neutral aprotic conditions

Various types of carbonyl compounds are efficiently converted to their 1,3-dioxanes and pentaerythritol diacetals by the use of either 1,3-bistrimethylsiloxy propane (A) or 1,3-bistrimethylsilanyloxy-2,2- bistrimethylsilanyloxymethyl propane (D) and a catalytic amount of N-bromosuccinimide (3-10 mol%) under essentially neutral aprotic condition, respectively. A variety of functionalities such as both aliphatic and phenolic -OTBDMS, -OMe, -OBz, furan ring, double bonds and more significantly phenolic -OTHP survived under the present reaction condition. The efficient conversion of two α-tertiary ketones to their cyclic acetals was also achieved using the present protocol.

Iodine-catalyzed, efficient and mild procedure for highly chemoselective acetalization of carbonyl compounds under neutral aprotic conditions

Various types of carbonyl compounds are efficiently converted to their 1,3-dioxanes by the use of 1,3-bis(trimethylsiloxy)propane (BTSP) and a catalytic amount of iodine (3-7 mol%) under essentially neutral aprotic condition.