56638-68-7

Upstream product

• 106-49-0 p-toluidine 
• 68-12-2 N,N-dimethyl-formamide 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 90619-09-3 C₈H₁₀N₂O 
• 1351220-40-0 C₁₅H₁₆N₂O 

Relevant academic research and scientific papers

Alkoxyamine-derived formamidines: Configurational control and molecular folding

N,N'-Disubstituted formamidines, and amidines in general, have very rich configurational, conformational, and tautomeric diversities. As part of an effort to incorporate alkoxyamine-derived formamidine units into foldamers, the first evidence for the isol

Formamidines - Versatile ligands for zinc-catalyzed hydrosilylation and iron-catalyzed epoxidation reactions

In the present study the abilities of catalysts modified by formamidine ligands have been examined in the zinc-catalyzed hydrosilylation of ketones and the iron-catalyzed epoxidation of stilbene, In case of hydrosilylation diethylzinc combined with easily accessible formamidine ligands allow for the efficient reduction of various aryl and alkyl ketones. By using a convenient in situ catalyst system high turnover frequencies up to more than 1.000 h -1 and a broad functional group tolerance were achieved. Moreover, the formamidine ligands were successfully applied, in the iron-catalyzed epoxidation of stilbene with hydrogen peroxide in good yield and chemoselectivity.

Oxidation of primary aromatic amines under irradiation with ultrasound and/or microwaves

The oxidation of primary aromatic amines, p-methylaniline, p-ethylaniline and p-chloroaniline to the corresponding azo- and azoxy-compounds has been observed in ultrasound and/or microwaves systems. The individual irradiation of microwaves and its simultaneous irradiation with ultrasound obviously elevate the conversion of amines, as compared with the individual irradiation of ultrasound and the heating in a plain water bath. However, the formation of formamidine resulted in poor selectivity toward azo and azoxy products in the presence of dimethylformamide (DMF). Copyright Taylor & Francis Group, LLC.

Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.

N-(4-Butyl-2-methylphenyl)-N'-hydroxyformamidine (HET0016) was evaluated as the first potent and selective inhibitor of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) synthase. The IC(50) value of HET0016 for the production of 20-HETE from arachidonic acid (AA) by human renal microsomes was 8.9+/-2.7 nM, with over 200 times the selectivity of xenobiotic-metabolizing cytochrome P450 enzymes. An examination of the structure-activity relationship revealed that the unsubstituted hydroxyformamidine moiety and the substituent at the para-position of the N-hydroxyformamidine moiety are necessary for the potent activity of HET0016.

Benzamidines, alkamidines and formamidines formed by use of aryl- and alkyliminodimagnesium: Molar ratio and structure of reagent governing the reaction

In order to extend the the method for preparation of amidines using N-Mg reagents, aryl- and alkyliminodimagnesium [IDMg, ArN(MgBr)2 and RN(MgBr)2] were reacted with esters, amides, ortho- esters, acetals, aminoacetal and arene- and