56643-78-8Relevant academic research and scientific papers
Synthesis and Antibacterial Evaluation of Bis-thiazolium, Bis-imidazolium, and Bis-triazolium Derivatives
Thomas, Beno?t,Duval, Rapha?l E.,Fontanay, Stéphane,Varbanov, Mihayl,Boisbrun, Michel
, p. 1232 - 1237 (2019)
Given the worldwide spread of bacterial drug resistance, there is an urgent need to develop new compounds that exhibit potent antibacterial activity and that are unimpaired by this phenomenon. Quaternary ammonium compounds have been used for many years as disinfectants, but recent advances have shown that polycationic derivatives exhibit much stronger activity and are less prone to bacterial resistance than commonly used monocationic compounds. In this sense, we prepared three series of new bis-cationic compounds: bis-thiazoliums, bis-imidazoliums, and bis-1,2,4-triazoliums. If some compounds of the first series showed fair antibacterial activity, most of those belonging to the two other series were highly potent, with minimum inhibitory concentrations close to 1 μg mL?1. Some of them also exhibited low toxicity toward eukaryotic MRC-5 lung fibroblasts, and we showed that this toxicity is clearly correlated with clogP. Finally, four selected compounds were found to exhibit a clear bactericidal effect.
Bis-diimidazolylidine complexes of nickel: Investigations into nickel catalyzed coupling reactions
Paulose, Tressia A. P.,Wu, Shih-Chang,Olson, Jeremy A.,Chau, Tony,Theaker, Nikki,Hassler, Matt,Quail, J. Wilson,Foley, Stephen R.
experimental part, p. 251 - 260 (2012/01/31)
Air and moisture stable homoleptic bis(diimidazolylidine)nickel(ii) complexes, ([(diNHC)2Ni]2+) 3a,b and their corresponding silver(i) 4a,b and palladium(ii) 5a,b complexes were synthesized and characterized by NMR and single crystal X-ray analysis. The catalytic potential of complex 3a was assessed in Mizoroki-Heck and Suzuki-Miyaura coupling reactions. In the Suzuki-Miyaura coupling reaction, nickel precatalyst 3a was active for the coupling of aryl chlorides as well as aryl fluorides. The analogously synthesized Pd(ii) complexes resulted in formation of (diNHC)PdCl2 species which were not active for the coupling of aryl fluorides. For the Mizoroki-Heck reaction, it was found that aryl iodides could be activated in the absence of nickel or palladium precatalysts when using Na2CO3 or NEt3 as base while aryl iodides and aryl bromides could be activated in the Suzuki-Miyaura reaction sans precatalyst when K3PO4 was used as base. The Royal Society of Chemistry.
Non-symmetrically substituted di-N-heterocyclic carbene palladium(II) complexes: Synthesis, structure and catalytic activity
Paulose, Tressia A.P.,Olson, Jeremy A.,Wilson Quail,Foley, Stephen R.
, p. 3405 - 3410 (2008/12/22)
The synthesis and characterization of non-symmetric di-N-heterocyclic carbene (diNHC) silver(I) and palladium(II) complexes are described. The activity of the Pd(II) complexes in the Suzuki-Miyaura coupling reaction of bulky substrates was investigated. This synthetic route represents a possible general pathway into a wide variety of non-symmetrically substituted diNHC ligands.
