56643-94-8

Upstream product

• 288-32-4 1H-imidazole 
• 824-98-6 m-methoxybenzyl chloride 
• 874-98-6 1-bromomethyl-3-methoxybenzene 

Downstream Products

• 109484-74-4 3-methoxyphenyl-(2-hydroxy-2-adamantyl)-1-imidazolylmethane 
• 1219012-65-3 C₁₉H₂₀N₂O₂Se 
• 1219012-64-2 C₁₉H₂₀N₂O₂S 
• 936216-39-6 2-iodo-1-(3-methoxybenzyl)-1H-imidazole 

Relevant academic research and scientific papers

PALLADIUM PINCER COMPLEX OF NORMAL AND ABNORMAL CARBENE, PREPARATION METHOD FOR THE SAME AND USES THEREOF

Palladium pincer complexes of both normal and abnormal carbene and preparation methods thereof are disclosed. Furthermore, uses of palladium pincer complexes of normal and abnormal carbene and pharmaceutical applications thereof are disclosed. Palladium pincer complex of normal and abnormal carbene are useful catalysts for C-C coupling reaction and therapeutic drugs for inhibiting tumor cell proliferation.

Palladium-catalyzed intramolecular arylation of N-benzyl-2-iodoimidazoles: A facile and rapid access to 5H-imidazo[2,1-α]isoindoles

The first example of a Pd-catalyzed intramolecular arylation involving the C-2 position of an imidazole ring is presented. Application of this reaction led to the formation of 5H-imidazo[2,1-a]isoindole in one step from N-benzyl-2-iodoimidazole. Microwave irradiation enhanced the rate of reaction allowing the synthesis of various imidazo[2,1-a]isoindole analogues. Georg Thieme Verlag Stuttgart.

IMIDAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS

The present invention relates to compounds of the formula (I), wherein R0 ; R1 ; R2 ; R3 ; R4; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

Palladium complexes with ethylene-bridged bis(N-heterocyclic carbene) for C-C coupling reactions

A series of new ethylene-bridged bis(imidazolium) halides with various N-substitutions were synthesized. Complexation of these imidazolium halides with Pd(OAc)2 produced new Pd(II) ethylene-bridged bis(carbene) complexes. Crystallographic analyses of some of the new imidazolium salts and Pd(II) complexes were determined. Applications of these seven-member palladacycles in Suzuki and Heck coupling reactions produced comparable catalytic activities to those of six-member analogs.