5666-89-7Relevant academic research and scientific papers
Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
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, (2008/06/13)
The present invention provides carboxylic acid derivatives of the general formula: STR1 wherein R is a hydrogen atom, alkyl, a metal cation or an ammonium or alkylammonium ion, R1 is a hydrogen atom, a hydroxyl group or an alkyl, O-alkyl,O-benzyl or O-acyl radical, R2 is a hydrogen atom or an alkyl, aryl or aralkyl radical, n is 0, 1 or 2 and R3 is an acyl radical, this radical being (a) a straight-chained or branched, saturated or unsaturated alkanoyl radical containing 2 to 11 carbon atoms; or (b) the radical STR2 in which A is a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon radical containing up to 4 carbon atoms, which is optionally substituted by hydroxyl, and B is a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon radical containing up to 8 carbon atoms, which is optionally substituted one or more times by hydroxyl, carboxyl or phenyl, or B is a phenyl or cycloalkyl radical; or (c) the radical STR3 in which A and B have the same meanings as in (b) and R4 is a hydrogen atom or an alkyl or aralkyl radical; as well as the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.
