56661-88-2

Basic information

• Product Name: METHYL 2-AMINO-1-CYCLOHEXENE-1-CARBOXYLATE
• Synonyms: METHYL 2-AMINO-1-CYCLOHEXENE-1-CARBOXYLATE;METHYL 2-AMINO-1-CYCLOHEXENE-1-CARBOXYLATE99%
• CAS NO: 56661-88-2
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.19
• Mol File: 56661-88-2.mol

Chemical Properties

• Melting Point: 50-53 °C
• Boiling Point: 279°C (rough estimate)
• Flash Point: 120.3°C
• Appearance: /
• Density: 1.1174 (rough estimate)
• Vapor Pressure: 0.00514mmHg at 25°C
• Refractive Index: 1.4890 (estimate)
• CAS DataBase Reference: METHYL 2-AMINO-1-CYCLOHEXENE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINO-1-CYCLOHEXENE-1-CARBOXYLATE(56661-88-2)
• EPA Substance Registry System: METHYL 2-AMINO-1-CYCLOHEXENE-1-CARBOXYLATE(56661-88-2)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 56661-88-2(Hazardous Substances Data)

Usage

Chemical Properties

YELLOW CRYSTALLINE POWDER

InChI:InChI=1/C8H13NO2/c1-11-8(10)6-4-2-3-5-7(6)9/h6,9H,2-5H2,1H3/b9-7+/t6-/m1/s1

Upstream product

• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 
• 40015-88-1 (1R,2S)-methyl 2-aminocyclohexanecarboxylate 

Downstream Products

• 917910-59-9 C₂₇H₃₇NO₄Si 
• 917910-79-3 C₂₆H₂₈N₄O₆ 
• 19178-19-9 5,6,7,8-tetrahydroquinazolin-4(3H)-one 
• 1208866-60-7 C₂₀H₂₂N₄O₅ 
• 1208866-68-5 C₂₇H₃₀N₄O₆ 

Relevant articles and documents

Synthesis and biochemical properties of E-ring modified luotonin a derivatives

Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotoni

Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial

Febrifugine, a quinazoline alkaloid isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. Although the use of ferifugine as an antimalarial drug has been precluded because of its severe side effects, its potent antimalarial activity has stimulated medicinal chemists to pursue its derivatives instead, which may provide valuable leads for novel antimalarial drugs. In the present study, we synthesized new derivatives of febrifugine and evaluated their in vitro and in vivo antimalarial activities to develop antimalarials that are more effective and safer. As a result, we proposed tetrahydroquinazoline-type derivative as a safe and effective antimalarial candidate.

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): A potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate

Biaryl cyclohexene carboxylic acids were discovered as full and potent niacin receptor (GPR 109A) agonists. Compound 1e (MK-6892) displayed excellent receptor activity, good PK across species, remarkably clean off-target profiles, good ancillary pharmacology, and superior therapeutic window over niacin regarding the FFA reduction versus vasodilation in rats and dogs.

Niacin receptor agonists, compositions containing such compounds and methods of treatment

The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.

Fused cycloalkylimidazopyridines

[6,7]-propylene-, -butylene- or -pentylene-fused imidazopyridin-4-amines that induce interferon (α) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (α) biosynthesis and treating viral infections involving the use of such compounds.