56680-20-7Relevant academic research and scientific papers
A Method to Access Symmetrical Tetrasubstituted Pyridines via Iodine and Ammonium Persulfate Mediated [2+2+1+1]-Cycloaddition Reaction
Liu, Weibing,Tan, Hua,Chen, Cui,Pan, Yupeng
supporting information, p. 1594 - 1598 (2017/05/05)
A novel metal-free [2+2+1+1]-cycloaddition method for rapid and productive preparation of symmetrical 2,3,5,6-tetrasubstituted pyridines has been developed from α-substituted arones and N,N-dimethyl formamide (DMF) using iodine (I2) and ammonium persulfate ((NH4)2S2O8) as mediators. In this process, both DMF and (NH4)2S2O8 play a dual role for the formation of pyridines. DMF acts as the reaction medium and the C4 source (the methyl group of DMF), while (NH4)2S2O8 serves as the oxidant and nitrogen resource. Notably, this transformation exhibited a broad substrate scope towards a wide variety of different arones to give the corresponding tetrasubstituted pyridines in moderate to excellent yields. (Figure presented.).
Ammonium iodide-promoted cyclization of ketones with DMSO and ammonium acetate for synthesis of substituted pyridines
Pan, Xiaojun,Liu, Qiao,Chang, Liming,Yuan, Gaoqing
, p. 51183 - 51187 (2015/06/25)
A simple and efficient method has been developed for the synthesis of symmetrical and unsymmetrical pyridines via NH4I-promoted cyclization of ketones with DMSO and NH4OAc. It was found that methyl ketones always gave selective forma
Ruthenium-catalyzed cyclization of ketoxime acetates with DMF for synthesis of symmetrical pyridines
Zhao, Mi-Na,Hui, Rong-Rong,Ren, Zhi-Hui,Wang, Yao-Yu,Guan, Zheng-Hui
, p. 3082 - 3085 (2014/06/23)
A novel ruthenium-catalyzed cyclization of ketoxime carboxylates with N,N-dimethylformamide (DMF) for the synthesis of tetrasubstituted symmetrical pyridines has been developed. A methyl carbon on DMF performed as a source of a one carbon synthon. And NaHSO3 plays a role in the reaction.
