566899-06-7Relevant academic research and scientific papers
Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis
Misawa, Takashi,Aoyama, Hiroshi,Furuyama, Taniyuki,Dodo, Kosuke,Sagawa, Morihiko,Miyachi, Hiroyuki,Kizaki, Masahiro,Hashimoto, Yuichi
experimental part, p. 1490 - 1495 (2009/10/01)
Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.
4,4′-Benzophenone-O,O′-disulfamate: A potent inhibitor of steroid sulfatase
Nussbaumer, Peter,Bilban, Melitta,Billich, Andreas
, p. 2093 - 2095 (2007/10/03)
We investigated whether the benzophenone moiety can be used as core element of steroid sulfatase (STS) inhibitors. While 4- and 3-benzophenone-O-sulfamates inhibit STS with IC50 values between 5 and 7 μM irrespective of additional hydroxy and m
