5669-78-3

Upstream product

• 61563-98-2 N-(p-chloropehenyl)-N-hydroxyacetoacetamide 
• 5869-60-3 α-(4-Chlor-benzolazo)-acetessigsaeure-ethylester 
• 18794-97-3 ethyl 2-(4-chlorophenylhydrazono)-3-oxobutyrate 
• 106-47-8 4-chloro-aniline 
• 1517-96-0 3-methyl-5-isoxazolone 

Downstream Products

• 51450-95-4 2-but-2-enoyl-4-(4-chloro-phenylazo)-3-methyl-2H-isoxazol-5-one 
• 112630-34-9 methyl 2-(4-chlorophenyl)-5-methyl-2H-1,2,3-triazole-4-carboxylate 
• 98664-19-8 4-(N-methyl-p-chlorophenylhydrazono)-3-methylisoxazol-5-one 
• 112630-31-6 (4-Chloro-phenyl)-(5-methoxy-3-methyl-isoxazol-4-yl)-diazene 
• 98664-20-1 2,3-dimethyl-4-(p-chlorophenylazo)isoxazol-5-one 

Relevant academic research and scientific papers

Aqueous phase synthesis, crystal structure and antimicrobial activity of 4-(substituted phenylazo)-3-methyl-4H-isoxazol-5-one azo dyes

3-Methyl-4H-isoxazol-5-one was synthesized at room temperature by simple stirring method from ethyl acetoacetate and hydroxylamine hydrochloride in aqueous medium and coupled with diazotized substituted amine to form series of 4-(substituted phenylazo)-3-methyl-4H-isoxazol-5-ones through green chemistry. All the compounds formed were characterized by IR, 1H and 13C NMR spectroscopy, MS and elemental analysis. Crystal structure of novel 4-(4-fluorophenylazo)-3-methyl-4H-isoxazol-5-one was determined by the X-ray diffraction. Antibacterial and antifungal activity was studied against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus pyogenus and Candida albicans, Aspergillus niger, Aspergillus clavatus, respectively. All synthesized compounds were found to be active against a gram-positive bacterium Staphylococcus aureus. Two compounds showed antifungal activity against Candida albicans close to standard greseofulvin.

Effects of temperature on the polarographic behaviour of 3-methyl-(4'-substiotuted-benzeneazo)-2-isoxazolin-5-ones

The polarographic behaviour of 3-methyl-4-(4'-substituted-benzeneazo)-2-isoxazolin-5-ones has been studied in 50 percent (v/v) dimethylfomamide solution in Britton-Robinson buffer of pH 4.1 at differnt temperatures (303.15-333.15 K). The reduction is found to be diffusion-controlled and irreversible at different temperatures. The shift of E1/2 values towards more negative potentials and decrease in the values of αna and kof,h suggest that the electrode reaction becomes more irreversible at elevated temperatures. The thermodynamic quantities have been evaluated.