566915-65-9Relevant academic research and scientific papers
Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties
Simoni, Daniele,Rondanin, Riccardo,Baruchello, Riccardo,Rizzi, Michele,Grisolia, Giuseppina,Eleopra, Marco,Grimaudo, Stefania,Di Cristina, Antonietta,Pipitone, Maria Rosaria,Bongiorno, Maria Rita,Aricò, Mario,Invidiata, Francesco Paolo,Tolomeo, Manlio
experimental part, p. 4796 - 4803 (2009/07/25)
A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.
A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol
Simoni, Daniele,Giannini, Giuseppe,Baraldi, Pier Giovanni,Romagnoli, Romeo,Roberti, Marinella,Rondanin, Riccardo,Baruchello, Riccardo,Grisolia, Giuseppina,Rossi, Marcello,Mirizzi, Danilo,Invidiata, Francesco Paolo,Grimaudo, Stefania,Tolomeo, Manlio
, p. 3005 - 3008 (2007/10/03)
A double Suzuki cross-coupling protocol has been devised as a practical route to a variety of terphenyls. Good chemoselectivity was observed. Unsymmetrically substituted triphenylenes were also easily prepared.
