566920-38-5Relevant articles and documents
Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore
Razavi, Hossein,Riether, Doris,Harcken, Christian,Bentzien, J?rg,Dinallo, Roger M.,Souza, Donald,Nelson, Richard M.,Kukulka, Alison,Fadra-Khan, Tazmeen N.,Pack Jr., Edward J.,Zuvela-Jelaska, Ljiljana,Pelletier, Josephine,Panzenbeck, Mark,Torcellini, Carol A.,Proudfoot, John R.,Nabozny, Gerald H.,Thomson, David S.
, p. 1934 - 1940 (2014/04/17)
Synthesis and structure-activity relationship (SAR) of a series of alkyl and cycloalkyl containing non-steroidal dissociated glucocorticoid receptor (GR) agonists is reported. This series of compounds was identified as part of an effort to replace the CF
GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
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Page/Page column 135, (2010/02/07)
Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate,or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
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Page 39-40, (2010/02/05)
A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical compositions containing such compounds,