566927-36-4Relevant academic research and scientific papers
Approaches toward the total synthesis of the nine-membered thio-lactone core of griseoviridin
Moreau, Xavier,Campagne, Jean-Marc
, p. 5346 - 5350 (2003)
Three different approaches toward the synthesis of the macrocyclic thiolactone core of griseoviridin have been studied. Intramolecular palladium-catalyzed thiol coupling and esterification (carboxylate activation) have led to the formation of unexpected rearranged products. An intermolecular palladium-catalyzed thiol/vinyl iodide coupling followed by an esterification (alcohol activation) ultimately led to the nine-membered core of griseoviridin.
