566938-91-8Relevant academic research and scientific papers
Practical phosphorylation methods for α,α-disubstituted α-amino alcohol derivatives
Ohnuki, Takashi,Tsuji, Takashi,Miyazaki, Shojiro,Moriguchi, Taku,Nishi, Takahide
scheme or table, p. 910 - 912 (2009/10/10)
We report herein practical phosphorylation methods for α,α- disubstituted α-amino alcohol derivatives which act as SIP1 receptor agonists. A novel direct phosphorylation method for α,α-disubstituted α-amino alcohol derivatives by biotransformat
AMINO ALCOHOL DERIVATIVE OR PHOSPHONIC ACID DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THESE
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Page 290, (2008/06/13)
The present invention relates to amino alcohol derivatives or phosphonic acid derivatives having excellent immunosuppressive activity, pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof, and to pharmaceutical compositions comprising said compounds as an active ingredient: [wherein, ???R1 and R2 each represent a hydrogen atom, or a protecting group of the amino group; ???R3 represents a hydrogen atom, or a protecting group of the hydroxyl group; ???R4 represents a lower alkyl group; ???n represents an integer of from 1 to 6; ???X represents an oxygen atom or a nitrogen atom unsubstituted or substituted with a lower alkyl group or the like; ???Y represents an ethylene group; ???Z represents a C1-C10 alkylene group; ???R5 represents an aryl group, or an aryl group substituted with substituents; ???R6 and R7 each represents a hydrogen atom; provided that when R5 represents a hydrogen atom, then Z represents a group other than a single bond or a straight chain C1-C10 alkylene group] .
