56703-33-4Relevant academic research and scientific papers
Discovery of new PPARγ agonists based on arylopeptoids
Worm-Leonhard, Kasper,Hjelmgaard, Thomas,Petersen, Rasmus K.,Kristiansen, Karsten,Nielsen, John
supporting information, p. 4162 - 4165 (2013/07/26)
In this study we present the design, synthesis and biological evaluation of a small, first-generation library of small molecule aromatic amides based on the arylopeptoid skeleton. The compounds were efficiently synthesized using a highly convenient submonomer solid-phase methodology which potentially allows for access to great product diversity. The synthesized compounds were tested for their ability to activate peroxisome proliferator-activated receptors (PPARs) and they all acted as PPARγ agonists in the μM range spanning from 2.5- to 14.7-fold activation of the receptor. This is the first discovery of bioactive molecules based on the arylopeptoid architecture.
trans-4-Stilbenecarboxylatoalkylpentaamminecobalt(III) perchlorates: Synthesis and intramolecular energy transfer
Parkanyi, Cyril,Huang, Lois Shiow-Chyn Yeh,Chu, Sung Gun,Jeffries III, Alfred T.
, p. 342 - 354 (2007/10/03)
Three homologs of tran-4-stilbenecarboxylic acid, viz., trans-4-stilbeneacetic acid (18), β-(trans-4-stilbene)propionic acid (19), and γ-trans-4-stilbene)butyric acid (20) were synthesized and, together with the parent trans-4-stilbenecarboxylic acid, use
