56718-71-9

Basic information

• Product Name: p-(2-Methoxyethyl) phenol
• Synonyms: P-ethyl ether;P-Methyl ether;Metoprolol Tartrate EP IMpurity-B;Metoprolol EP IMpurity B;Phenol,4-(2-Methoxyethyl)-;The Methoxy ethyl phenol;4-(2-Methoxyethyl)Phenol (56781-17-9);p-Hydroxyphenethyl methyl ether
• CAS NO: 56718-71-9
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.19
• EINECS: 260-354-9
• Product Categories: Metabolites & Impurities;Pharmaceuticals;Organic Building Blocks;Oxygen Compounds;Phenols;Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Aromatic Phenols;Phenoles and thiophenoles;Various Metabolites and Impurities;Intermediates & Fine Chemicals
• Mol File: 56718-71-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 42-45 °C(lit.)
• Boiling Point: 125 °C / 3mmHg
• Flash Point: >230 °F
• Appearance: White Powder
• Density: 1.06 g/cm³
• Vapor Pressure: 0.0252mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 10.00±0.15(Predicted)
• Water Solubility: 8.42g/L at 20℃
• CAS DataBase Reference: p-(2-Methoxyethyl) phenol(CAS DataBase Reference)
• NIST Chemistry Reference: p-(2-Methoxyethyl) phenol(56718-71-9)
• EPA Substance Registry System: p-(2-Methoxyethyl) phenol(56718-71-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 56718-71-9(Hazardous Substances Data)

Usage

Chemical Properties

White Low Melting Solid

Uses

Different sources of media describe the Uses of 56718-71-9 differently. You can refer to the following data:
1. 4-(2-Methoxyethyl)phenol is an Impurity of Metoprolol.
2. 4-(2-Methoxyethyl)phenol may be used in the preparation of methyl analog of metoprolol (MAM).

General Description

4-(2-Methoxyethyl)phenol can be prepared by reacting methyl vinyl ether and 4-bromonitrobenzene.

InChI:InChI=1/C9H12O2/c1-11-7-6-8-2-4-9(10)5-3-8/h2-5,10H,6-7H2,1H3

Synthetic route

alpha-methoxy-4-hydroxyacetophenone (32136-81-5) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol under 2327.2 Torr; for 4h;	96%
With hydrogen under 3000.3 Torr; Pressure; Heating;	80%
With hydrogen; acetic acid; palladium on activated charcoal
With H2; acetic acid; palladium-carbon	0.54 g (3.6 mmol=61%)

4-hydroxyphenyl glyoxal dimethylacetal → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
palladium-carbon In hydrogenchloride; methanol	70%
With hydrogen; palladium-carbon In hydrogenchloride; methanol	59%
With hydrogen; palladium-carbon In methanol	53%
With hydrogenchloride; hydrogen; palladium-carbon In methanol	47%

p-hydroxyphenethyl alcohol (501-94-0) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
With sulfuric acid In methanol	40%
In methanol	31%
Multi-step reaction with 3 steps 1: ethanol / 9 h / Heating 2: 1.) NaH / 1.) THF, reflux, 30 min; 2.) THF, reflux, 6 h 3: H2 / 10percent Pd/C / ethanol / 24 h / 3102.9 Torr / Ambient temperature View Scheme

4-(2-methoxyethenyl)phenol → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
With hydrogen In ethyl acetate at 50℃; under 30402 Torr; for 16h;	10 g

methanol (67-56-1) + 4-(2-chloroethyl)phenol (28145-35-9) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
With sodium methylate at 50℃; for 7h; Reagent/catalyst;	92%

1-(benzyloxy)-4-(2-methoxyethyl)benzene (98627-35-1) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
With palladium on activated charcoal; hydrogen In tetrahydrofuran at 20℃; under 3000.3 Torr; for 24h;	82%
With hydrogen; palladium on activated charcoal In ethanol under 3102.9 Torr; for 24h; Ambient temperature;
With palladium 10% on activated carbon; hydrogen under 37503.8 Torr; for 3h;	38.6 g

2-(4'-hydroxyphenyl)ethyl methyl carbonate (953422-33-8) + carbonic acid dimethyl ester (616-38-6) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
With Amberlyst 15 for 36h; Reflux;	95%

p-hydroxyphenethyl alcohol (501-94-0) + sodium hydrogencarbonate (144-55-8) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
In methanol	65%

methanol (67-56-1) + 4-((3H-diazirin-3-yl)methyl)phenol → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
at 20℃; for 2h; Inert atmosphere; UV-irradiation;	57%

4-(2-bromoethyl)phenol (14140-15-9) + sodium methylate (124-41-4) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
In methanol at 20℃; for 3h;	79%
With methanol

p-hydroxyphenethyl alcohol (501-94-0) + poly(styrene-co-divinylbenzene)-supported methyl sulfonate, loading rate of SO3Me: ca. 4.0 mmol/g → 2-(4-Methoxyphenyl)ethanol (702-23-8) + 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
With potassium carbonate In acetonitrile for 24h; Heating;	A 82% B 9%

L-tyrosine (60-18-4) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia; [bis(acetoxy)iodo]benzene / methanol / 2 h / 0 - 20 °C / Inert atmosphere 2: 2 h / 20 °C / Inert atmosphere; UV-irradiation View Scheme

L-<15N>tyrosine (35424-81-8) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia; [bis(acetoxy)iodo]benzene; potassium hydroxide / methanol / 2 h / 0 °C 2: 2 h / 20 °C / Inert atmosphere; UV-irradiation View Scheme

2-(4-benzyloxyphenyl)ethanol (61439-59-6) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) THF, reflux, 30 min; 2.) THF, reflux, 6 h 2: H2 / 10percent Pd/C / ethanol / 24 h / 3102.9 Torr / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: potassium hydroxide / dimethyl sulfoxide / 20 °C 2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 24 h / 20 °C / 3000.3 Torr View Scheme

phenol (108-95-2) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: 50 percent / AlCl3 / various solvent(s) / 5 h / 70 °C 2: 90 percent / methanol / 24 h / Ambient temperature 3: 96 percent / H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride 2: methanol / pH 8 3: hydrogen / 3000.3 Torr / Heating View Scheme

2-bromo-1-(4'-hydroxyphenyl)-1-ethanone (2491-38-5) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol 2: H2; AcOH / Pd/C View Scheme

4-Hydroxyacetophenone (99-93-4) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: CuBr2 / ethyl acetate 2: methanol 3: H2; AcOH / Pd/C View Scheme

p-hydroxyphenacyl chloride (6305-04-0) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / methanol / 24 h / Ambient temperature 2: 96 percent / H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr View Scheme

Acetic acid 4-(2-methoxy-ethyl)-phenyl ester (82099-82-9) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
With sodium hydroxide In ethanol for 4h; Heating;
With sodium hydroxide

2-phenylethanol (60-12-8) + ZnCl2 → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 4 steps 2: NaOH 3: H2O2, HCOOH 4: NaOH View Scheme
Multi-step reaction with 6 steps 1: 207 g / pyridine / benzene / 5 h / 25 - 30 °C 2: 218 g / aluminium chloride / CH2Cl2 / 6 h / Ambient temperature 3: 71 g / sodium hydroxide / ethanol / 5 h / Heating 4: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C 5: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 6: sodium hydroxide / ethanol / 4 h / Heating View Scheme

1-<4-(1-hydroxyethyl)phenyl>ethanone (99215-51-7) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: NaOH 2: H2O2, HCOOH 3: NaOH View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C 2: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 3: sodium hydroxide / ethanol / 4 h / Heating View Scheme

4-methoxyethylacetophenone (93205-89-1) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: H2O2, HCOOH 2: NaOH View Scheme
Multi-step reaction with 2 steps 1: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 2: sodium hydroxide / ethanol / 4 h / Heating View Scheme

4-chloro-phenol (106-48-9) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 1.2: 1 h / 105 °C 2.1: magnesium; iodine / 2-methyltetrahydrofuran / 2 h / Reflux 3.1: sodium hydroxide / toluene; water / 2 h 3.2: 2 h 4.1: palladium 10% on activated carbon; hydrogen / 3 h / 37503.8 Torr View Scheme
Multi-step reaction with 4 steps 1.1: sulfuric acid / toluene / 16 h / -10 - 0 °C 2.1: magnesium / tetrahydrofuran / 16 h / 65 - 72 °C / Inert atmosphere 2.2: 0 - 10 °C / Inert atmosphere 3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 55 - 60 °C 4.1: sodium methylate / 7 h / 50 °C View Scheme

para-nitrophenyl bromide (586-78-7) + magnesium → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) Et3N, 2.) H2 / 1/2.) 5percent Pd/C / 1.) toluene, 120 deg C, 16 h, 2.) toluene, 85 deg C, 150 psi, 45 min 2: 1.) NaNO2, 50percent H2SO4, 2.) urea / 1.) H20, 5 deg C, 15 min, 2.) H2O, 100 - 105 deg C, 1 h View Scheme

β-(4-acetylphenyl)ethyl acetate (73823-79-7) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 4 steps 1: 71 g / sodium hydroxide / ethanol / 5 h / Heating 2: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C 3: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 4: sodium hydroxide / ethanol / 4 h / Heating View Scheme

acetic acid phenethyl ester (103-45-7) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 5 steps 1: 218 g / aluminium chloride / CH2Cl2 / 6 h / Ambient temperature 2: 71 g / sodium hydroxide / ethanol / 5 h / Heating 3: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C 4: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 5: sodium hydroxide / ethanol / 4 h / Heating View Scheme

4-chlorophenyl benzyl ether (7700-27-8) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: magnesium; iodine / 2-methyltetrahydrofuran / 2 h / Reflux 2.1: sodium hydroxide / toluene; water / 2 h 2.2: 2 h 3.1: palladium 10% on activated carbon; hydrogen / 3 h / 37503.8 Torr View Scheme

4-tert-butoxychlorobenzene (18995-35-2) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: magnesium / tetrahydrofuran / 16 h / 65 - 72 °C / Inert atmosphere 1.2: 0 - 10 °C / Inert atmosphere 2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 55 - 60 °C 3.1: sodium methylate / 7 h / 50 °C View Scheme

4-tert-butoxybromobenzene (60876-70-2) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: magnesium / tetrahydrofuran / 6 h / 65 - 72 °C / Inert atmosphere 1.2: 0 - 10 °C / Inert atmosphere 2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 55 - 60 °C 3.1: sodium methylate / 7 h / 50 °C View Scheme

4-bromo-phenol (106-41-2) → 4-(2-methoxyethyl)phenol (56718-71-9)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sulfuric acid / toluene / 16 h / -10 - 0 °C 2.1: magnesium / tetrahydrofuran / 6 h / 65 - 72 °C / Inert atmosphere 2.2: 0 - 10 °C / Inert atmosphere 3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 55 - 60 °C 4.1: sodium methylate / 7 h / 50 °C View Scheme

4-(2-methoxyethyl)phenol (56718-71-9) + 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile (244768-32-9) → 4-{4-[4-(2-methoxylethyl)phenoxy]pyrimidin-2-ylamino}benzonitrile (1448695-92-8)

Conditions	Yield
Stage #1: 4-(2-methoxyethyl)phenol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	98.4%

succinic acid (110-15-6) + 4-(2-methoxyethyl)phenol (56718-71-9) + isopropylamine (75-31-0) + epichlorohydrin (106-89-8) → metoprolol succinate

Conditions	Yield
Stage #1: 4-(2-methoxyethyl)phenol; epichlorohydrin With sodium hydroxide In water at 30 - 40℃; for 5h; Stage #2: isopropylamine In water at 20 - 30℃; for 5h; Stage #3: succinic acid In acetone at 20 - 35℃; Temperature; Solvent;	97.8%

3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one (6637-53-2, 144252-21-1, 144252-22-2) + 4-(2-methoxyethyl)phenol (56718-71-9) → 3-(2-hydroxy-5-(2-methoxyethyl)phenyl)-3-phenylisoindolin-1-one

Conditions	Yield
Stage #1: 3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one With methanesulfonic acid In cyclohexane at 25℃; for 0.166667h; Betti Reaction; Stage #2: 4-(2-methoxyethyl)phenol In cyclohexane at 80℃; for 16h; Betti Reaction;	97%

4-(4-chloro-6-methyl-pyrimidin-2-ylamino)-benzonitrile + 4-(2-methoxyethyl)phenol (56718-71-9) → 4-{6-methyl-4-[4-(2-methoxylethyl)phenoxy]pyrimidin-2-ylamino}benzonitrile (1448695-99-5)

Conditions	Yield
Stage #1: 4-(2-methoxyethyl)phenol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 4-(4-chloro-6-methyl-pyrimidin-2-ylamino)-benzonitrile In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	96.2%

4-(2-methoxyethyl)phenol (56718-71-9) + epichlorohydrin (106-89-8) → 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane (56718-70-8)

Conditions	Yield
With sodium hydroxide at 85 - 90℃; pH=8; Temperature; pH-value; Flow reactor;	95.2%
With sodium hydroxide at 90 - 115℃; under 1500.15 - 2250.23 Torr; pH=9; Flow reactor;	95.2%
With sodium hydroxide In water at 40 - 45℃; for 3 - 5h;	93%

4-(2-methoxyethyl)phenol (56718-71-9) + allyl bromide (106-95-6) → 3-[4-(2-methoxyethyl)phenoxy]propylene (80448-05-1)

Conditions	Yield
With potassium carbonate In acetone Reflux;	87%
With potassium carbonate In acetone for 7h; Heating;	85%

formic acid (64-18-6) + 4-(2-methoxyethyl)phenol (56718-71-9) → 4-(2-Methoxyethyl)phenyl formate

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium acetate; acetic anhydride at 20℃; for 12h; Inert atmosphere;	87%

4-(2-methoxyethyl)phenol (56718-71-9) + C14H19N2O2S(1+)*F6P(1-) → 4-(2-methoxyethyl)phenyl-4-methylbenzenesulfonate

Conditions	Yield
With DBN In acetonitrile at 80℃; for 4h;	84%

1,1,1,2,3,3-hexafluoro-2-(heptafluoropropoxy)-3-[(trifluorovinyl)oxy]propane (1644-11-7) + 4-(2-methoxyethyl)phenol (56718-71-9) → 1-(2-methoxy-ethyl)-4-[1,1,2-trifluoro-2-(1,1,2,3,3,3-hexafluoro-2-heptafluoropropyloxy-propoxy)-ethoxy]-benzene

Conditions	Yield
With potassium hydroxide Addition;	78%

formic acid (64-18-6) + iodobenzene (591-50-4) + 4-(2-methoxyethyl)phenol (56718-71-9) → 4-(2-methoxyethyl)phenyl benzoate

Conditions	Yield
With palladium diacetate; acetic anhydride; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 80℃; for 12h; Inert atmosphere;	78%

(S)-epichlorohydrin (67843-74-7) + 4-(2-methoxyethyl)phenol (56718-71-9) → (2S)-2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane (105780-38-9) + (R)-2-{[4-(2-methoxyethyl)phenoxy]methyl}oxirane (133397-54-3)

Conditions	Yield
With potassium carbonate In acetonitrile for 14h; Reflux; optical yield given as %ee;	A n/a B 75%

4-(2-methoxyethyl)phenol (56718-71-9) + (S,S,S)-triglycidyl isocyanurate → (S)-5-((4-(2-methoxyethyl)phenoxy)methyl)oxazolidin-2-one (1333949-81-7)

Conditions	Yield
With potassium hydroxide In 4-methyl-2-pentanone at 110 - 115℃; for 2 - 3h; Large scale reaction;	75%

(R)-(-)-epichlorohydrin (51594-55-9) + 4-(2-methoxyethyl)phenol (56718-71-9) → (2S)-2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane (105780-38-9) + (R)-2-{[4-(2-methoxyethyl)phenoxy]methyl}oxirane (133397-54-3)

Conditions	Yield
With potassium carbonate In acetonitrile for 14h; Reflux; optical yield given as %ee;	A 73% B n/a

4-(2-methoxyethyl)phenol (56718-71-9) + (4S)-N-tert-butoxycarbonyl-4-[[(4'-methylbenzenesulfonyl)oxy]methyl]-2,2-dimethyl-1,3-oxazolidine (140645-28-9) → 4(R)-4-((4-(2-methoxyethyl)phenoxy)methyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (935547-68-5)

Conditions	Yield
Stage #1: 4-(2-methoxyethyl)phenol With sodium hydride In N,N-dimethyl-formamide at 20℃; Stage #2: (4S)-N-tert-butoxycarbonyl-4-[[(4'-methylbenzenesulfonyl)oxy]methyl]-2,2-dimethyl-1,3-oxazolidine In N,N-dimethyl-formamide at 40℃; for 1h;	71%
With sodium hydride In N,N-dimethyl-formamide at 60 - 80℃;
Stage #1: 4-(2-methoxyethyl)phenol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: (4S)-N-tert-butoxycarbonyl-4-[[(4'-methylbenzenesulfonyl)oxy]methyl]-2,2-dimethyl-1,3-oxazolidine In N,N-dimethyl-formamide at 60 - 80℃; for 2h; Further stages.;

1-(6-chloro-5-nitro-pyrimidin-4-yl)-piperidine-4-carboxylic acid ethyl ester (733747-96-1) + 4-(2-methoxyethyl)phenol (56718-71-9) → 1-{6-[4-(2-methoxyethyl)-phenoxy]-5-nitropyrimidin-4-yl}-piperidine-4-carboxylic acid ethyl ester (733748-32-8)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 15h;	71%

Upstream product

• 14140-15-9 4-(2-bromoethyl)phenol 
• 124-41-4 sodium methylate 
• 32136-81-5 alpha-methoxy-4-hydroxyacetophenone 
• 82099-82-9 Acetic acid 4-(2-methoxy-ethyl)-phenyl ester 
• 108-95-2 phenol 
• 953422-33-8 2-(4'-hydroxyphenyl)ethyl methyl carbonate 
• 616-38-6 carbonic acid dimethyl ester 
• 106-48-9 4-chloro-phenol 
• 7700-27-8 4-chlorophenyl benzyl ether 
• 67-56-1 methanol 
• 28145-35-9 4-(2-chloroethyl)phenol 
• 18995-35-2 4-tert-butoxychlorobenzene 
• 60876-70-2 4-tert-butoxybromobenzene 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 56718-70-8 2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane 
• 56718-76-4 (+/-)-1-[4-(2-methoxyethyl)phenoxy]-3-chloro-2-propanol 
• 105780-38-9 (2S)-2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane 
• 548765-61-3 methyl-phenyl-carbamic acid 4-(2-methoxy-ethyl)-phenyl ester 
• 87130-01-6 4-(2-methoxyethyl)-phenoxy-acetaldehyde 
• 733748-32-8 1-{6-[4-(2-methoxyethyl)-phenoxy]-5-nitropyrimidin-4-yl}-piperidine-4-carboxylic acid ethyl ester 
• 1339949-16-4 (S)-1-bromo-3-[4-(2-methoxy-ethyl)-phenoxy]-propan-2-ol 
• 113798-79-1 (R)-1-bromo-3-[4-(2-methoxy-ethyl)-phenoxy]-propan-2-yl acetate 
• 1006885-95-5 (S)-metoprolol 
• 81024-42-2 S-(-)-metoprolol 
• 1628935-01-2 4-(but-2-ynyloxy)-4-(2-methoxyethyl)cyclohexa-2,5-dienone 
• 1333949-81-7 (S)-5-((4-(2-methoxyethyl)phenoxy)methyl)oxazolidin-2-one 

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To the methoxy ethyl phenol synthesis method (by machine translation)

The invention discloses a method for synthesizing methoxy ethyl phenol, to the chlorophenol as the starting material, through the phenolic hydroxyl protection, format reaction, methylation and hydrogenation debenzylation reaction to obtain the target product to the methoxy ethyl phenol process, the methylation reaction is just a simple filtering operation that can be used for the next step reaction, without any other operation. This invention adopts the [...] as the starting material to synthesize to methoxy ethyl phenol, reduce the difficulty of after treatment, reduce the reaction time, the product has high purity, high yield, good stability of the product. (by machine translation)