5672-61-7Relevant academic research and scientific papers
COMPLEX HYDRIDE REDUCTIONS OF 12-OXOSTEROIDS. INFLUENCE OF REMOTE SUBSTITUENTS
Biesemans, M.,Woude, G. Van de,Hove, L. van
, p. 29 - 40 (2007/10/02)
A number of 12-oxosteroids with both 5α- and 5β-configuration and with variable side chain are reduced with LiAlH4, NaAlH4 and Li in THF and diethylether.The ratio of the epimeric 12-alcohols obtained, exhibits a remarkable dependence on the type of A/B ring fusion and on the C-17 substitution.An evaluation of these effects is made in the light of generally accepted rationalizations on the mechanism of ketone reductions by hydride reagents.
