5674-04-4Relevant academic research and scientific papers
Copper-catalyzed asymmetric conjugate addition with Grignard reagents and SimplePhos ligands
Palais, Laetitia,Alexakis, Alexandre
experimental part, p. 2866 - 2870 (2010/04/05)
Herein we report the copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic and acyclic enones, with SimplePhos as chiral ligands. A variety of Grignard reagents can be added to a range of cyclic and acyclic enones, with moderate to good enantioselectivities (ee's up to 86%).
Beryllium dichloride: Efficient promoter for the addition of organolithiums and organomagnesiums to cyclohexen-2-one
Krief, Alain,De Vos, Marie Joelle,De Lombart, Stephane,Bosret, Jean,Couty, Francois
, p. 6295 - 6298 (2007/10/03)
Organoberyllium compounds, generated by transmetallation from Grignard and organolithium reagents react with 2-cyclohexenone to give predominantly the adducts resulting from conjugated addition. The chemoselectivity of this reaction was found to be highly dependent upon the nature of organic moiety and of the conditions used.
ALKYL METAL ASYMMETRIC REDUCTION. 11. THE REACTION OF α,β-UNSATURATED KETONES WITH β-BRANCHED TRIALKYLALUMINIUM COMPOUNDS.
Giacomelli, Giampaolo,Caporuso, Anna Maria,Lardicci, Luciano
, p. 3663 - 3666 (2007/10/02)
The reduction of a series of α,β-unsaturated ketones has been studied under various experimental conditions, by using β-branched trialkylalanes.Asymmetric induction phenomena are observed when optically active trialkylalanes are used.
