56745-61-0

Basic information

• Product Name: 2-Hexanone, 5-hydroxy- (6CI,9CI)
• Synonyms: 2-Hexanone, 5-hydroxy- (6CI,9CI);5-HYDROXY-2-HEXANONE;2-Hexanone, 5-hydroxy-;5-hydroxyhexan-2-one
• CAS NO: 56745-61-0
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.16
• Product Categories: ACETYLGROUP
• Mol File: 56745-61-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: -3.75°C (estimate)
• Boiling Point: 212.22°C (estimate)
• Flash Point: 81.152 °C
• Appearance: /
• Density: 0.9626
• Vapor Pressure: 0.0583mmHg at 25°C
• Refractive Index: 1.4312
• CAS DataBase Reference: 2-Hexanone, 5-hydroxy- (6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexanone, 5-hydroxy- (6CI,9CI)(56745-61-0)
• EPA Substance Registry System: 2-Hexanone, 5-hydroxy- (6CI,9CI)(56745-61-0)

Safety Data

• Hazardous Substances Data: 56745-61-0(Hazardous Substances Data)

Usage

Definition

ChEBI: A ketone that is hexan-2-one in which one of the hydrogens at position 5 is replaced by a hydroxy group.

InChI:InChI=1/C6H12O2/c1-5(7)3-4-6(2)8/h5,7H,3-4H2,1-2H3

Upstream product

• 2935-44-6 hexane-2,5-diol 
• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 110-13-4 2,5-hexanedione 
• 59416-72-7 3,6-dimethyl-1,2-dioxacyclohexane 

Downstream Products

• 110-13-4 2,5-hexanedione 
• 65709-73-1 (5R)-hydroxyhexane-2-one 

Relevant articles and documents

Insight into the hydrogenation of pure and crude HMF to furan diols using Ru/C as catalyst

5-hydroxymethylfurfural (HMF) is one of the most important renewable platform-chemicals, a very valuable precursor for the synthesis of bio-fuels and bio-products. In this work, the hydrogenation of HMF to two furan diols, 2,5-bis(hydroxymethyl)furan (BHMF) and 2,5-bis(hydroxymethyl)tetrahydrofuran (BHMTHF), both promising renewable monomers, was investigated. Three commercial catalysts, Ru/C, Pd/C and Pt/C, were tested in the hydrogenation of aqueous HMF solutions (2–3 wt%), using a metal loading of 1 wt% respect to HMF content. By appropriate tuning of the process conditions, either BHMF or BHMTHF were obtained in good yields, and Ru/C resulted the best catalyst for this purpose, allowing us to obtain BHMF or BHMTHF yields up to 93.0 and 95.3 mol%, respectively. This catalyst was also tested for in the hydrogenation of a crude HMF-rich hydrolyzate, obtained by one-pot the dehydration of fructose. The influence of each component of this hydrolyzate on the hydrogenation efficiency was investigated, including unconverted fructose, rehydration acids and humins, in order to improve the yields towards each furan diol. Moreover, ICP-OES and TEM analysis showed that the catalyst was not subjected to important leaching and sintering phenomena, as further confirmed by catalyst recycling study.

Efficient desymmetrization of 1,2 and 1,3 diols by dimethyldioxirane

Dimethyldioxirane was used to monooxide 1,2 and 1,3 sec,sec-diols to the corresponding ketoalcohols, exploiting the inhibiting effect of the formed carbonyl group on the course of the process.

Meerwein-Ponndorf-Verley-Type Reduction of Dicarbonyl Compounds to Hydroxy Carbonyl Compounds and α,β-Unsaturated Carbonyl Compounds to Allylic Alcohols Catalyzed by Zirconocene and Hafnocene Complexes

Group IVA metallocene complexes such as bis(η5-cyclopentadienyl)zirconium dihydrides, Cp2ZrH2 (1), and hafnium dihydrides, Cp2HfH2 (8), catalyze the chemoselective reduction of polycarbonyl compounds to hydroxy carbonyl compounds.For instance, the reduction of keto aldehydes 3-ketobutanal (2g) and 2-phenyl-2-ketoethanal (2h) proceeded selectively at aldehyde group to provide the corresponding hydroxy ketones 3g and 3h in 91percent and 93percent yields, respectively.Under similar conditions, however, cyclohexanediones were easily aromatized to benzenediols.On the other hand, 1 and 8 also catalyze the selective 1,2-reduction of various types of α,β-unsaturated carbonyl compounds, giving the corresponding allylic alcohols in good to excellent yields.Thus, steroidal dicarbonyl compounds, having an enone framework in their molecules Δ4-androstene-3,17-dione (11a) and Δ4-progestene-3,20-dione (11b) were reduced by 1 to 17-hydroxy-Δ4-androsten-3-one (12a) and 20-hydroxy-Δ4-progest-3-one (12b), which are essential human hormones, in 80percent and 67percent yields, respectively.