5676-56-2

Usage

Uses

Used in Scientific Research:
5-Bromo-2-methylbenzodoxazole is used as a research compound for its unique chemical properties. It aids in the study of aromatic organic molecules and their interactions, contributing to the advancement of chemical knowledge and understanding.
Used in Product Development:
In the field of product development, 5-Bromo-2-methylbenzodoxazole is employed as a key intermediate or building block in the synthesis of various chemical products. Its unique structure allows for the creation of new compounds with potential applications in different industries.
Used in Pharmaceutical Industry:
5-Bromo-2-methylbenzodoxazole is used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its unique structure and properties make it a valuable component in the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
5-Bromo-2-methylbenzodoxazole is used as a reagent in various chemical synthesis processes. Its versatility in reacting with other compounds allows for the creation of a wide range of products, from dyes to polymers, with potential applications in various industries.
Used in Material Science:
In material science, 5-Bromo-2-methylbenzodoxazole is used as a component in the development of new materials with specific properties. Its unique structure contributes to the creation of materials with potential applications in electronics, coatings, and other advanced technologies.

InChI:InChI=1/C8H6BrNO/c1-5-10-7-4-6(9)2-3-8(7)11-5/h2-4H,1H3

Upstream product

• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 40925-68-6 2-amino-4-bromo-phenol 
• 123-54-6 acetylacetone 

Downstream Products

• 845872-30-2 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole 
• 61931-68-8 2-methyl-5-phenylbenzo[d]oxazole 
• 903556-80-9 2-methylbenzo[d]oxazole-5-carbonitrile 
• 931-88-4 1,2-cyclooctene 
• 628710-94-1 4-methoxy-3-(2-methylbenzoxazol-5-yl)benzenecarboxaldehyde 

Relevant academic research and scientific papers

Acid Catalyzed Direct-Amidation-Dehydrocyclization of 2-Hydroxy-acetophenones to Benzoxazoles by a One-Pot Sustainable Synthesis

A series of 2-methyl-benzoxazoles have been synthesized starting from 2-hydroxy-acetophenones via a one-pot three steps reaction. Hydroxylamonium salt has been used as amidation agent. The reaction occurs with different anions, but the best results is achieved with hydroxylamonium hydrchloride. Despite the number of consecutive stages, the reaction is highly selective. Mild reaction conditions and various solvents can be used, but trifluoroacetic acid is the preferred. Almost, complete recovery of the trifluoroacetic acid can be achieved by vacuum distillation. The role of trifluoroacetic acid, as well as, of the hydroxylamonium salt suggests a cooperative effect leading to high selective formation of 2-methyl-benzoxazoles. Graphical Abstract: One-pot TFA catalyzed synthesis of benzoxazoles starting from 2-hydroxyacetophenones. (Chemical Equation Presented).

Synthesis of benzoxazoles from 2-aminophenols and β-diketones using a combined catalyst of br?nsted acid and copper iodide

Cyclization reactions of 2-aminophenols with β-diketones catalyzed by a combination of Br?nsted acid and CuI are presented. Various 2-substituted benzoxazoles were obtained through these reactions. Different substituents such as methyl, chloro, bromo, nitro, and methoxy on 2-aminophenol are tolerated under the optimized reaction conditions.

Microwave-assisted efficient one-step synthesis of amides from ketones and benzoxazoles from (2-hydroxyaryl) ketones with acetohydroxamic acid using sulfuric acid as the catalyst

Efficient one-step method for the synthesis of amides directly from ketones and benzoxazoles from (2-hydroxyaryl) ketones by the reaction of acetohydroxamic acid using sulfuric acid as catalyst was described.