56764-07-9Relevant articles and documents
A Cyclopropenethione-Phosphine Ligation for Rapid Biomolecule Labeling
Row, R. David,Prescher, Jennifer A.
, p. 5614 - 5617 (2018)
Cyclopropenethiones are reported as new bioorthogonal reagents. These motifs react readily with substituted phosphines to provide thiocarbonyl adducts. In some cases, the ligations are >300-fold faster than analogous reactions with bioorthogonal cyclopropenones. Dialkyl cyclopropenethiones are also stable in aqueous buffers and can be used for biomolecule labeling in vitro and in cell lysate. The rapid reactivity and biocompatibility of cyclopropenethiones suggest that they will be useful probes for cellular studies.
Acylthiocyclopropenium Ions
Yoshida, Hiroshi,Nakajima, Mikito,Ogata, Tsuyoshi,Matsumoto, Kiyoshi
, p. 1973 - 1974 (2007/10/02)
On treatment with a mixture of thiocarboxylic acid and perchloric acid in acetic anhydride, cyclopropenone gave acylthiocyclopropenium perchlorate in a good yield.Bis(acylthio)cyclopropene also yielded the salt under similar reaction conditions.The salt was stable under nitrogen at low temperatures, but was easily hydrolyzed to yield the corresponding cyclopropenethione.