56772-85-1

Upstream product

• 56772-78-2 1-(2,2-dichlorovinyl)-2-methoxybenzene 
• 3167-62-2 diethyl (dichloromethyl)phosphonate 
• 135-02-4 ortho-anisaldehyde 
• 767-91-9 1-ethynyl-2-methoxybenzene 

Downstream Products

• 1314145-20-4 C₁₃H₁₂BrClO 
• 1313869-26-9 (Z)-2-chloro-1-(2-methoxyphenyl)penta-1,4-dienyl acetate 

Relevant academic research and scientific papers

An improved transition-metal-free synthesis of aryl alkynyl sulfides via substitution of a halide at an sp-centre

A simple high-yielding preparation of aryl alkynyl sulfides is presented. The reaction of a chloroacetylene with a thiolate salt in the presence of an amine mediator (dimethylamine or N,N′-dimethylethylenediamine) yields the alkynyl sulfides in excellent yields. The alkynyl chloride is easily prepared from the parent alkyne.

An improved synthesis of dichloroalkylphosphonates, chloroalkynes and terminal alkynes via diethyl dichloromethylphosphonate

Diethyl 1,1-dichloromethylphosphonate (2) was synthesised in good yield from the reduction of 1,1,1-trichloromethylphosphonate (1) with i-C3H7MgCl and subsequent hydrolysis. The reactivity of 2 towards α-alkylation and its utility in the synthesis of chloroalkynes and terminal alkynes was investigated.