56776-55-7

Basic information

• Product Name: 2-methyl-N-phenylbenzenesulfonamide
• Synonyms: 2-methyl-N-phenylbenzenesulfonamide
• CAS NO: 56776-55-7
• Molecular Formula: C₁₃H₁₃NO₂S
• Molecular Weight: 247.31282
• Mol File: 56776-55-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 397.4°Cat760mmHg
• Flash Point: 194.1°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 1.59E-06mmHg at 25°C
• Refractive Index: 1.621
• PKA: 8.57±0.10(Predicted)
• CAS DataBase Reference: 2-methyl-N-phenylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N-phenylbenzenesulfonamide(56776-55-7)
• EPA Substance Registry System: 2-methyl-N-phenylbenzenesulfonamide(56776-55-7)

Safety Data

• Hazardous Substances Data: 56776-55-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H13NO2S/c1-11-7-5-6-10-13(11)17(15,16)14-12-8-3-2-4-9-12/h2-10,14H,1H3

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 98-95-3 nitrobenzene 
• 62-53-3 aniline 
• 88-19-7 methyl 2-(aminosulfonyl)benzoate 
• 59-88-1 phenylhydrazine hydrochloride 
• 133-59-5 Toluene-2-sulfonyl chloride 
• 873-55-2 sodium benzenesulfonate 
• 18684-09-8 toluene-sulphonic acid hydrazide 
• 108-94-1 cyclohexanone 
• 591-50-4 iodobenzene 

Downstream Products

• 54437-71-7 N-methyl-N-phenyl-2-methylbenzenesulfonamide 
• 88-19-7 methyl 2-(aminosulfonyl)benzoate 
• 92851-27-9 N-Acetyl-N-phenyl-o-toluolsulfonamid 
• 860699-37-2 2-phenylsulfamoyl-benzoic acid 
• 31848-21-2 1,1-dioxo-2-phenyl-1,4-dihydro-2H-1λ⁶-benzo[e][1,2]thiazin-3-one 

Relevant articles and documents

Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration

We describe a new strategy for aminoarylation of alkenes by copper-catalyzed smiles rearrangement using O-benzoylhydroxylamines as the amine reagent. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition.

Sequential C-S and S-N Coupling Approach to Sulfonamides

A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts.

Copper-catalyzed denitrogenative N-arylation of sulfoximines and sulfonamides with arylhydrazines

A Cu-mediated ligand-free arylation of NH-sulfoximines and sulfonamides by arylhydrazine hydrochlorides was herein demonstrated. The oxidative transformation provided an easy access towards N-aryl sulfoximines and sulfonamides in high yields (up to 93% yields) with broad functional groups tolerance (up to 36 examples). The protocol was proposed to take place through the free radical pathway based on the results of control reactions and EPR analysis.