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2-phenyl-2,6,7,8-pentahydro-3H-pyrido[1,2-a]pyrimidin-4-one is a complex organic compound belonging to the pyrido[1,2-a]pyrimidin-4-one family. It is characterized by a pentahydro core, which means it contains five hydrogen atoms attached to a six-membered ring. The molecule features a phenyl group attached to the 2-position, which is a benzene ring with a single bond to the rest of the molecule. The pyrido[1,2-a]pyrimidin-4-one structure is a fused ring system, with a pyridine ring fused to a pyrimidine ring at the 1 and 2 positions. The 3H-pyrido[1,2-a]pyrimidin-4-one part indicates that the molecule has a hydrogen atom at the 3 position, which is part of a three-membered ring. The compound is known for its potential applications in medicinal chemistry, particularly as a scaffold for the development of new drugs, due to its unique structure and the ability to form various functional groups.

5678-69-3

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5678-69-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5678-69-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,7 and 8 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5678-69:
(6*5)+(5*6)+(4*7)+(3*8)+(2*6)+(1*9)=133
133 % 10 = 3
So 5678-69-3 is a valid CAS Registry Number.

5678-69-3Downstream Products

5678-69-3Relevant academic research and scientific papers

Synthesis and structure-activity relationships of vasicine analogues as bronchodilatory agents

Mahindroo, Neeraj,Ahmed, Zabeer,Bhagat, Asha,Bedi, Kasturi Lal,Khajuria, Ravi Kant,Kapoor, Vijay Kumar,Dhar, Kanaya Lal

, p. 347 - 368 (2007/10/03)

The series of vasicine (1) analogues, an alkaloid from Adhatoda vasica Nees., were synthesized with changes in A, B or C rings. Compounds 3-19 were evaluated for in vitro bronchodilatory activity using isolated guinea pig tracheal chain. Compounds 3-8 were also synthesized in good yields using microwave-mediated synthesis under solvent free conditions. Compounds 5 and 8 with seven-member C ring were more active than etofylline and caused 100% relaxation of both the histamine and acetylcholine pre-contracted guinea pig tracheal chain. The structure-activity relationship studies showed that the quinazoline and oxo functionalities were essential for activity. The compounds without C ring and instead having aliphatic and phenyl substitutions in B ring showed relaxation against histamine pre-contracted tracheal chain only, 2-methyl substituted analogues, 12 and 13, being most active with 100% relaxation effect. Birkhaeuser Boston 2006.

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