Galloflavin, also known as Tannic acid, is a primary gallo-tannin derived from hydrolyzable tannins found in gall nuts and various plant sources. It possesses weak acidic properties and a strong astringent taste. Its hydroxy and carboxy groups enable interactions with biopolymers and macromolecules, making it a promising pharmaceutical candidate for various applications.
568-80-9
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Basic information
- Product Name: Galloflavin
- Synonyms: Galloflavin;3,8,9,10-Tetrahydroxy-pyrano[3,2-c][2]benzopyran-2,6-dione;NSC 107022;6,8,9,10-tetrahydroxypyrano[3,2-c]isochromene-2,3-dione;3,8,9,10-Tetrahydroxy-pyrano[3,2-c][2]benzopyran-2,6-dione,NSC 107022
- CAS NO:568-80-9
- Molecular Formula: C12H6O8
- Molecular Weight: 278.17124
- EINECS: N/A
- Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File: 568-80-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 159.8°Cat760mmHg
- Flash Point: 37.4°C
- Appearance: light yellow to light brown/
- Density: 2.1g/cm3
- Vapor Pressure: 0.862mmHg at 25°C
- Refractive Index: 1.848
- Storage Temp.: ?20°C
- Solubility: DMSO: soluble5mg/mL, clear
- CAS DataBase Reference: Galloflavin(CAS DataBase Reference)
- NIST Chemistry Reference: Galloflavin(568-80-9)
- EPA Substance Registry System: Galloflavin(568-80-9)
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Safety Data
- Hazard Codes: Xn
- Statements: 22
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 568-80-9(Hazardous Substances Data)
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568-80-9 Usage
Uses
Used in Anticancer Applications:Galloflavin is used as a novel inhibitor of lactate dehydrogenase (LDH) for its potential anticancer properties. It is particularly effective against solid malignancies and is suitable for LDH-related research.
Used in Pharmaceutical Research:
Galloflavin is used as a pharmaceutical candidate for its interactions with biopolymers and macromolecules, making it a promising agent for various applications in the pharmaceutical industry.
Used in Drug Delivery Systems:
Galloflavin can be employed in the development of novel drug delivery systems to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles can be used as carriers for Galloflavin delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Biochem/physiol Actions
Galloflavin is an inhibitor of lactate dehydrogenase (LDH). The compound blocks both isoforms of (LDH-A and –B) with Ki values of 5.5 and 15 μM, respectively. Inhibition of the glycolytic pathway by galloflavin induces oxidative stress and apoptosis in breast tumor cell lines.Check Digit Verification of cas no
The CAS Registry Mumber 568-80-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.Calculate Digit Verification of CAS Registry Number 568-80:
(5*5)+(4*6)+(3*8)+(2*8)+(1*0)=89
89 % 10 = 9
So 568-80-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H6O8/c13-4-1-3-7(9(16)8(4)15)10-6(19-11(3)17)2-5(14)12(18)20-10/h1-2,13,15-17H
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Galloflavin
