5681-17-4

Basic information

• Product Name: 4-(4-ethoxy-3-methoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one
• CAS NO: 5681-17-4
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.3426
• Mol File: 5681-17-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 468.3°C at 760 mmHg
• Flash Point: 197.4°C
• Density: 1.18g/cm³
• Vapor Pressure: 6.03E-09mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 4-(4-ethoxy-3-methoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-ethoxy-3-methoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(5681-17-4)
• EPA Substance Registry System: 4-(4-ethoxy-3-methoxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one(5681-17-4)

Safety Data

• Hazardous Substances Data: 5681-17-4(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 

Downstream Products

• 110664-46-5 1-<3-Methoxy-4-aethoxy-phenyl>-3-<3-methoxy-4-aethoxy-benzoyl>-propan 
• 115143-83-4 1-Acetoxy-1,4-bis-(3-methoxy-4-ethoxy-phenyl)-butan 
• 102473-36-9 6-Methoxy-7-ethoxy-1-(3-methoxy-4-ethoxy-phenyl)-tetralin 
• 115388-21-1 1-Hydroxy-1,4-bis-(3-methoxy-4-ethoxy-phenyl)-butan 
• 102662-88-4 6-Methoxy-7-ethoxy-1-(3-methoxy-4-ethoxy-phenyl)-naphthalin 
• 77891-29-3 2-(4-ethoxy-3-methoxyphenyl)ethanol 
• 103502-24-5 3-Methoxy-4-ethoxy-1-(2-brom-ethyl)-benzol 
• 55761-07-4 methyl 4-ethoxy-3-methoxyphenylacetate 

Relevant articles and documents

Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones

Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 1-27 were evaluated for their activity against Leishmania major. Compounds 1-27 demonstrated in vitro antileishmanial activities with IC50 values between 28.9 - 69.05 μM, as compared to standard drug pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 12 (IC50 = 28.90 ± 1.10 μM), 24 (IC50 = 31.4 ± 2.15 μM), 13 (IC50 = 35.0 ± 3.18 μM), 16 (IC50 = 35.0 ± 3.13 μM), and 25 (IC50 = 35.0 ± 3.18μM) displayed signifiant antileishmanial activities. Whereas, compounds 8-10, 15, 19, and 26 with IC50 values of 62.2 ± 3.36, 57.8 ± 2.30, 57.72 ± 5.02, 56.18 ± 4.40, 57.85 ± 2.25, 69.05 ± 6.20, 54.8 ± 1.50, and 57.8 ± 2.30 μM showed a moderate antileishmanial activities.