56816-94-5Relevant academic research and scientific papers
Atom-Economical Dimerization Strategy by the Rhodium-Catalyzed Addition of Carboxylic Acids to Allenes: Protecting-Group-Free Synthesis of Clavosolide A and Late-Stage Modification
Haydl, Alexander M.,Breit, Bernhard
supporting information, p. 15530 - 15534 (2016/01/26)
Natural products of polyketide origin with a high level of symmetry, in particular C2-symmetric diolides as a special macrolactone-based product class, often possess a broad spectrum of biological activity. An efficient route to this important
Pd-catalyzed asymmetric β-hydride elimination en route to chiral allenes
Crouch, Ian T.,Neff, Robynne K.,Frantz, Doug E.
supporting information, p. 4970 - 4973 (2013/06/04)
We wish to report our preliminary results on the discovery and development of a catalytic, asymmetric β-hydride elimination from vinyl Pd(II)-complexes derived from enol triflates to access chiral allenes. To achieve this, we developed a class of chiral p
Copper-Catalyzed Conjugate Addition of Trimethylaluminium to α,β-Unsaturated Ketones
Kabbara, Jazid,Flemming, Steffen,Nickisch, Klaus,Neh, Harribert,Westermann, Juergen
, p. 1489 - 1494 (2007/10/02)
The conjugate methylation of α,β-unsaturated ketones with trimethylaluminium occurs smoothly in a very simple procedure under the catalytic CuI salts.Scope and limitations of this process as well as the influence of solvent and catalyst on the kinetics were studied.In addition, the effect of chlorotrimethylsilane as an additive was investigated.Attack on the carbonyl group in 1,2-fashion could not be observed under the reaction conditions.- Key Words: Conjugate alkylation / Trimethylaluminium / Copper catalysis
