56820-70-3

Usage

Uses

Used in Chemical Synthesis:
6-Chloro-1-hydroxynaphthalene is used as an intermediate in the production of various dyes, pigments, and pharmaceuticals. It plays a crucial role in the synthesis of other organic compounds, making it a common reagent in organic chemistry reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-Chloro-1-hydroxynaphthalene is used as a key intermediate for the synthesis of various drugs. Its unique chemical structure allows for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Dye and Pigment Industry:
6-Chloro-1-hydroxynaphthalene is employed as a starting material in the production of dyes and pigments. Its chemical properties enable the creation of a wide range of colorants used in various industries, including textiles, plastics, and printing inks.
Used in Environmental Management:
Due to its potential hazards as a chemical irritant and environmental pollutant, 6-Chloro-1-hydroxynaphthalene is also used in the development of methods for its safe handling, storage, and disposal. This helps in minimizing its impact on the environment and human health.

Upstream product

• 88-14-2 2-furanoic acid 
• 90500-14-4 5-chloro-2-iodosobenzoic acid 
• 117573-47-4 6-chloro-1,4-dihydro-1,4-epoxynaphthalene 
• 26673-31-4 6-chloro-3,4-dihydronaphthalen-1(2H)-one 
• 91-66-7 N,N-diethylaniline 

Downstream Products

• 2050-72-8 1,6-dichloronaphthalene 
• 56820-57-6 2-Bromo-7-chloro-l-tetralone 
• 56820-58-7 7-chloro-[1]naphthol 
• 56820-67-8 5-chloro-2-(chloroformyl)-cis-cinnamonitrile 

Relevant academic research and scientific papers

Photocatalytic hydrogen evolution of 1-tetralones to α-naphthols by continuous-flow technology

Taking advantage of the synergy between photocatalysis and cobaloxime catalysis, the keto-enol radical cation of 1-tetralones becomes compatible with the transformation of various 1-tetralones into α-naphthols and H2 by virtue of the continuous-flow approach without any sacrificial oxidants under unusually mild conditions.

Picomolar inhibitors of HIV-1 reverse transcriptase: Design and crystallography of naphthyl phenyl ethers

Catechol diethers that incorporate a 6-cyano-1-naphthyl substituent have been explored as non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). Promising compounds are reported that show midpicomolar activity against the wild-type virus and sub-20 nM activity against viral variants bearing Tyr181Cys and Lys103Asn mutations in HIV-RT. An X-ray crystal structure at 2.49 ? resolution is also reported for the key compound 6e with HIV-RT.

ARYNIC SPECIES II; TOSYL AND TRIAZENE AS LEAVING GROUP IN THE GENERATION OF ARYNES FROM POLYMER-BOUND REAGENTS

o-Benzyne and its 4-methyl, 4-chloro and 4-bromo-derivatives were generated in the thermal decomposition of two new kinds of polymer-bound precursors: 1(2-carboxyaryl)triazenes and 2-carboxyaryl-sulphonates.New kinds of trapping polymers for these elusive

ARYNIC SPECIES; EFFECT OF SUBSTITUENTS ON THE REACTIVITY OF MONOSUBSTITUTED DEHYDROBENZENES

Evidence is presented demonstrating the existence of free dehydrobenzenes in the thermal decomposition of diaryliodonium-2-carboxylates, and that o-benzyne itself and its 4-methyl-, 4-chloro-, 4-bromo- and 4-nitro-derivatives are generated from insoluble polymer-bound precursors and trapped by a second solid phase in Diels-Alder reactions.Lifetimes for these elusive species are determined.

GENERATION OF MONOSUBSTITUTED o-BENZYNES FROM POLYMERIC REAGENTS VIA HETEROLYTIC FRAGMENTATIONS

Generation of four 4-substituted o-benzynes by heterolytic fragmentation reactions is demonstrated.