5685-18-7

Usage

Molecular weight

355.39 g/mol

Physical state

Crystalline solid

Use in organic synthesis

Starting material for various pharmacologically active compounds

Use in pharmaceutical research

Production of active compounds

Use in polymer synthesis

Building block for specialty chemicals

Importance in organic chemistry

Versatile and widely used compound

Potential applications

Drug development, creation of specialty chemicals

Upstream product

• 21765-43-5 2,2-diphenyl-succinic acid-4-methyl ester 
• 14702-32-0 α,α-diphenylsuccinic acid anhydride 
• 62-53-3 aniline 
• 86-29-3 Diphenylacetonitrile 
• 10186-26-2 2,2-diphenylsuccinic acid 
• 33925-44-9 β-cyano-β,β-diphenylpropionic acid 
• 33925-43-8 ethyl β-cyano-β,β-diphenylpropionate 

Relevant academic research and scientific papers

Solvatochromic and quantum chemical investigations of newly synthesized succinimides: Substituent effect on intramolecular charge transfer

Two series of 1-aryl-3-phenyl- and 1-aryl-3,3-diphenylpyrrolidine-2,5- diones were synthesized and their solvatochromic properties were studied in a set of 15 solvents of different polarity. The effect of specific and non-specific solvent-solute interacti

Reversed-phase TLC and HPLC retention data in correlation studies with in silico molecular descriptors and druglikeness properties of newly synthesized anticonvulsant succinimide derivatives

The properties relevant to pharmacokinetics of two series of newly synthesized succinimide derivatives have been studied. The properties under consideration have been either determined empirically, by reversed-phase liquid chromatography (TLC and HPLC technique), or calculated with the use of established theoretical medicinal chemistry/drug design software. Chromatographic techniques allowed determination of the retention constants RM0 and log kw, which characterize lipophilicity of compounds. Considering potential pharmaceutical importance of succinimide derivatives, we (i) examined the retention behavior in the reversed-phase liquid chromatographic (RP LC) systems, in both planar and column LC, and (ii) determined the relationships between chromatographic data and selected structural features of analytes that are believed to markedly affect their processes of absorption, distribution, metabolism, excretion and toxicity (ADMETox). Significant relationships were found between the retention constants, RM0 and log kw, and the in silico calculated bioactivity descriptors, in particular HIA (human intestinal absorption) and PPB (plasma protein binding) parameters. The RM0 and log kw values of the investigated compounds have been recommended for description of their lipophilicity and evaluating pharmacokinetic properties. In view of results of this study the newly synthesized succinimide agents meet pharmacokinetic criteria of preselection of drug candidates and hence qualify for pharmacodynamic phase of antiepileptic drug development. Best compromising human intestinal absorption and plasma protein binding features appear to be compounds A4, A5, A10 and A11.