568551-29-1Relevant articles and documents
An easy access to the exocyclic lactams analogous of the central nervous system active tricyclic nitroxapine, mianserine and chlothiapine agents using N-acyliminium chemistry
Hadou, Abderrahmane,Hamid, Abdulkareem,Mathouet, Hilarion,Deida, Mohamed-Fadel,Daich, Adam
scheme or table, p. 1017 - 1022 (2009/06/28)
The conformationally restrained dibenzothia(oxa)zepines and dibenzazepines 4-6 analogous to the antidepressant Sintamil were prepared easily by π-cationic cyclization of the N-acyliminium ions 9A-C precursors with neat trifluoroacetic acid in three step-sequence starting from available amines and anhydrides. The regioselectivity in the reduction of imides especially in the maleimide derivatives as well as in the cyclization step was also discussed.
