568588-48-7

Basic information

• Product Name: 1,2-Cyclohexanedicarboxamide, N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]-, (1S,2S)-
• CAS NO: 568588-48-7
• Molecular Formula: C24H30N2O4
• Molecular Weight: 410.513
• Mol File: 568588-48-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2-Cyclohexanedicarboxamide, N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]-, (1S,2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclohexanedicarboxamide, N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]-, (1S,2S)-(568588-48-7)
• EPA Substance Registry System: 1,2-Cyclohexanedicarboxamide, N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]-, (1S,2S)-(568588-48-7)

Safety Data

• Hazardous Substances Data: 568588-48-7(Hazardous Substances Data)

Upstream product

• 2305-32-0 trans-1,2-cyclohexanedicarboxylic acid 
• 610-10-6 (1S,2S)-cyclohexane-1,2-dicarboxylic acid 
• 46021-27-6 (1S,2S)-cyclohexane-1,2-dicarbonyl dichloride 
• 20989-17-7 (2S)-2-phenylglycinol 
• 186581-53-3 diazomethane 

Downstream Products

• 568588-45-4 (S,S)-1,2-bis[(S)-(4-phenyl)-1,3-oxazolin-2-yl]cyclohexane 

Relevant articles and documents

Rational tuning chelate size of bis-oxazoline ligands to improve enantioselectivity in the asymmetric aziridination of chalcones

Chalcones were asymmetrically aziridinated with [N-(p-toluenesulfonyl) imino]phenyliodinane (PhI=NTs) as a nitrene source under catalysis of CuOTf and a series of cyclohexane-linked bis-oxazolines (cHBOXes), which are chelate size rationally tuned bis-oxazolines. The results indicate that highly enantioselective aziridination of chalcones with up to >99% ee have been achieved under catalysis of (S,S)-1,2-bis[(S)-(4-phenyl)oxazolin-2-yl] cyclohexane, which is the most-matched stereoisomer among cyclohexane-linked bis-oxazolines. It was also found that the enantioselectivity is not substituent-dependent with respect to chalcones in the present case, unlike with 1,8-anthracene-linked bis-oxazolines (AnBOXes).